Globo-A--a new receptor specificity for attaching Escherichia coli.
FEBS Lett
; 237(1-2): 123-7, 1988 Sep 12.
Article
em En
| MEDLINE
| ID: mdl-3049148
ABSTRACT
Uropathogenic Escherichia coli strains designated as ONAP, based on their O negative A positive agglutination of human P1 erythrocytes, were shown to prefer the globo-A glycolipid as a receptor structure. The dependence on both the A terminal and the globoseries chain was confirmed by agglutination of human AP1, but not Ap or OP1 erythrocytes and by binding to the globo-A glycolipid on TLC plates. Neither Gal alpha 1----4Gal beta nor the A trisaccharide GalNAc alpha 1----3(Fuc alpha 1----2)Gal beta alone functioned as receptors. The bacteria thus appeared to recognize an epitope resulting from the combination of the terminal and internal structures.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Grupos Sanguíneos
/
Aderência Bacteriana
/
Glicolipídeos
/
Glicoesfingolipídeos
/
Escherichia coli
/
Globosídeos
/
Hemaglutinação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Suécia