Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1.

Sanchez, Julie; E Huma, Zil; Lane, J Robert; Liu, Xuyu; Bridgford, Jessica L; Payne, Richard J; Canals, Meritxell; Stone, Martin J

Sanchez, Julie; E Huma, Zil; Lane, J Robert; Liu, Xuyu; Bridgford, Jessica L; Payne, Richard J; Canals, Meritxell; Stone, Martin J.

Afiliação

Sanchez J; From the Infection and Immunity Program, Monash Biomedicine Discovery Institute, and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
E Huma Z; the Drug Discovery Biology Program, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Lane JR; From the Infection and Immunity Program, Monash Biomedicine Discovery Institute, and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Liu X; the Drug Discovery Biology Program, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Bridgford JL; the Drug Discovery Biology Program, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Payne RJ; the Centre for Membrane Proteins and Receptors, Nottingham University, Nottingham NG7 2UH, United Kingdom.
Canals M; the School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia, and.
Stone MJ; From the Infection and Immunity Program, Monash Biomedicine Discovery Institute, and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

J Biol Chem ; 294(10): 3464-3475, 2019 03 08.

Article em En | MEDLINE | ID: mdl-30567735

Assuntos

Modelos Moleculares; Receptores CCR1/química; Receptores CCR1/metabolismo; Motivos de Aminoácidos; Sequência de Aminoácidos; Linhagem Celular; Humanos; Ligantes; Ligação Proteica; Especificidade por Substrato

Palavras-chave

CCR1; G protein-coupled receptor (GPCR); binding; chemokine; chemokine receptor; cytokine; innate immunity; molecular pharmacology; receptor activation; receptor structure-function; signaling; three-step model

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modelos Moleculares / Receptores CCR1 Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália

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