A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis.
Neuropsychopharmacology
; 44(7): 1274-1283, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30647449
ABSTRACT
Nestled within feeding circuits, the oval (ov) region of the Bed Nucleus of the Stria Terminalis (BNST) may be critical for monitoring energy balance through changes in synaptic strength. Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of male rats, seesawing between long-term potentiation (iLTP, fed) and depression (iLTD, food restricted). L-α-lysophosphatidylinositol (LPI) acting on GPR55 receptors and 2-arachidonoylglycerol (2-AG) through CB1R were respectively responsible for fed (iLTP) and food restricted (iLTD) states. Thus, we have characterized a potential gating mechanism within the ovBNST that may signal metabolic state within the rat brain feeding circuitry.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resposta de Saciedade
/
Núcleos Septais
/
Receptores Acoplados a Proteínas G
/
Receptores de Canabinoides
/
Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Revista:
Neuropsychopharmacology
Assunto da revista:
NEUROLOGIA
/
PSICOFARMACOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Canadá