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A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration.
Das, Soumyashree; Goldstone, Andrew B; Wang, Hanjay; Farry, Justin; D'Amato, Gaetano; Paulsen, Michael J; Eskandari, Anahita; Hironaka, Camille E; Phansalkar, Ragini; Sharma, Bikram; Rhee, Siyeon; Shamskhou, Elya Ali; Agalliu, Dritan; de Jesus Perez, Vinicio; Woo, Y Joseph; Red-Horse, Kristy.
Afiliação
  • Das S; Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Goldstone AB; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Wang H; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Farry J; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • D'Amato G; Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Paulsen MJ; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Eskandari A; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Hironaka CE; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Phansalkar R; Department of Biology, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
  • Sharma B; Department of Biology, Ball State University, Muncie, IN 47306, USA.
  • Rhee S; Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Shamskhou EA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Agalliu D; Departments of Neurology, Pathology and Cell Biology, and Pharmacology, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • de Jesus Perez V; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Woo YJ; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: joswoo@stanford.edu.
  • Red-Horse K; Department of Biology, Stanford University, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: kredhors@stanford.edu.
Cell ; 176(5): 1128-1142.e18, 2019 02 21.
Article em En | MEDLINE | ID: mdl-30686582
ABSTRACT
Collateral arteries are an uncommon vessel subtype that can provide alternate blood flow to preserve tissue following vascular occlusion. Some patients with heart disease develop collateral coronary arteries, and this correlates with increased survival. However, it is not known how these collaterals develop or how to stimulate them. We demonstrate that neonatal mouse hearts use a novel mechanism to build collateral arteries in response to injury. Arterial endothelial cells (ECs) migrated away from arteries along existing capillaries and reassembled into collateral arteries, which we termed "artery reassembly". Artery ECs expressed CXCR4, and following injury, capillary ECs induced its ligand, CXCL12. CXCL12 or CXCR4 deletion impaired collateral artery formation and neonatal heart regeneration. Artery reassembly was nearly absent in adults but was induced by exogenous CXCL12. Thus, understanding neonatal regenerative mechanisms can identify pathways that restore these processes in adults and identify potentially translatable therapeutic strategies for ischemic heart disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Circulação Colateral / Coração Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regeneração / Circulação Colateral / Coração Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos