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Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.
Ballinger, Elaine; Mosior, John; Hartman, Travis; Burns-Huang, Kristin; Gold, Ben; Morris, Roxanne; Goullieux, Laurent; Blanc, Isabelle; Vaubourgeix, Julien; Lagrange, Sophie; Fraisse, Laurent; Sans, Stéphanie; Couturier, Cedric; Bacqué, Eric; Rhee, Kyu; Scarry, Sarah M; Aubé, Jeffrey; Yang, Guangbin; Ouerfelli, Ouathek; Schnappinger, Dirk; Ioerger, Thomas R; Engelhart, Curtis A; McConnell, Jennifer A; McAulay, Kathrine; Fay, Allison; Roubert, Christine; Sacchettini, James; Nathan, Carl.
Afiliação
  • Ballinger E; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
  • Mosior J; Departments of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX, USA.
  • Hartman T; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Burns-Huang K; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
  • Gold B; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
  • Morris R; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Goullieux L; Infectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
  • Blanc I; Infectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
  • Vaubourgeix J; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
  • Lagrange S; Infectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
  • Fraisse L; Infectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
  • Sans S; Infectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
  • Couturier C; Infectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
  • Bacqué E; Infectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
  • Rhee K; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Scarry SM; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
  • Aubé J; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
  • Yang G; Organic Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Ouerfelli O; Organic Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Schnappinger D; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
  • Ioerger TR; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
  • Engelhart CA; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
  • McConnell JA; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
  • McAulay K; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
  • Fay A; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Roubert C; Infectious Diseases Therapeutic Area, Sanofi, Marcy-l'Étoile, France.
  • Sacchettini J; Departments of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX, USA. cnathan@med.cornell.edu sacchett@tamu.edu.
  • Nathan C; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA. cnathan@med.cornell.edu sacchett@tamu.edu.
Science ; 363(6426)2019 02 01.
Article em En | MEDLINE | ID: mdl-30705156
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Ureia / Coenzima A / Transferases (Outros Grupos de Fosfato Substituídos) / Guanidina / Hidrolases / Mycobacterium tuberculosis Limite: Animals Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Ureia / Coenzima A / Transferases (Outros Grupos de Fosfato Substituídos) / Guanidina / Hidrolases / Mycobacterium tuberculosis Limite: Animals Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos