Viability Screen of LOPAC<sup>1280</sup> Reveals Tyrosine Kinase Inhibitor Tyrphostin A9 as a Novel Partner Drug for Artesunate Combinations To Target the <i>Plasmodium falciparum</i> Ring Stage.

Tong, Jie Xin; Ang, Sarah E L; Tan, Esther H N; Tan, Kevin S W

Viability Screen of LOPAC¹²⁸⁰ Reveals Tyrosine Kinase Inhibitor Tyrphostin A9 as a Novel Partner Drug for Artesunate Combinations To Target the Plasmodium falciparum Ring Stage.

Tong, Jie Xin; Ang, Sarah E L; Tan, Esther H N; Tan, Kevin S W.

Afiliação

Tong JX; Laboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ang SEL; Laboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Tan EHN; Laboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Tan KSW; Laboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore mictank@nus.edu.sg.

Antimicrob Agents Chemother ; 63(4)2019 04.

Article em En | MEDLINE | ID: mdl-30718250

Assuntos

Artesunato/farmacologia; Malária Falciparum/tratamento farmacológico; Plasmodium falciparum/efeitos dos fármacos; Inibidores de Proteínas Quinases/farmacologia; Proteínas Tirosina Quinases/antagonistas & inibidores; Tirfostinas/farmacologia; Antimaláricos/farmacologia; Resistência a Medicamentos/efeitos dos fármacos; Genótipo; Humanos; Malária Falciparum/parasitologia; Mutação/genética; Plasmodium falciparum/genética; Proteínas de Protozoários

Palavras-chave

Plasmodium falciparum; artemisinin resistance; artesunate; drug combination; drug screening; malaria; ring stage; tyrphostin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Proteínas Tirosina Quinases / Malária Falciparum / Tirfostinas / Inibidores de Proteínas Quinases / Artesunato Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Singapura

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google