Toxicokinetics of N-ethyl-2-pyrrolidone and its metabolites in blood, urine and amniotic fluid of rats after oral administration.

Bury, Daniel; Saillenfait, Anne Marie; Marquet, Fabrice; Käfferlein, Heiko U; Brüning, Thomas; Koch, Holger M

Bury, Daniel; Saillenfait, Anne Marie; Marquet, Fabrice; Käfferlein, Heiko U; Brüning, Thomas; Koch, Holger M.

Afiliação

Bury D; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Saillenfait AM; National Research and Safety Institute, 1 rue du Morvan, CS 60027, 54519, Vandoeuvre Cedex, France.
Marquet F; National Research and Safety Institute, 1 rue du Morvan, CS 60027, 54519, Vandoeuvre Cedex, France.
Käfferlein HU; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany. kaefferlein@ipa-dguv.de.
Brüning T; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Koch HM; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.

Arch Toxicol ; 93(4): 921-929, 2019 04.

Article em En | MEDLINE | ID: mdl-30729276

Assuntos

Líquido Amniótico/química; Substâncias Perigosas; Placenta/metabolismo; Pirrolidinonas; Administração Oral; Animais; Relação Dose-Resposta a Droga; Feminino; Substâncias Perigosas/sangue; Substâncias Perigosas/toxicidade; Substâncias Perigosas/urina; Masculino; Troca Materno-Fetal; Placenta/efeitos dos fármacos; Gravidez; Pirrolidinonas/sangue; Pirrolidinonas/toxicidade; Pirrolidinonas/urina; Ratos Sprague-Dawley; Toxicocinética

Palavras-chave

Amniotic fluid; N-Ethyl-2-pyrrolidone (NEP); Plasma; Rats; Toxicokinetics; Urine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Placenta / Pirrolidinonas / Substâncias Perigosas / Líquido Amniótico Tipo de estudo: Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Revista: Arch Toxicol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha

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