Single-neuron axonal reconstruction: The search for a wiring diagram of the brain.
J Comp Neurol
; 527(13): 2190-2199, 2019 09 01.
Article
em En
| MEDLINE
| ID: mdl-30859571
ABSTRACT
Reconstruction of the axonal projection patterns of single neurons has been an important tool for understanding both the diversity of cell types in the brain and the logic of information flow between brain regions. Innovative approaches now enable the complete reconstruction of axonal projection patterns of individual neurons with vastly increased throughput. Here, we review how advances in genetic, imaging, and computational techniques have been exploited for axonal reconstruction. We also discuss how new innovations could enable the integration of genetic and physiological information with axonal morphology for producing a census of cell types in the mammalian brain at scale.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axônios
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Encéfalo
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Neuroimagem
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Vias Neurais
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Comp Neurol
Ano de publicação:
2019
Tipo de documento:
Article