Lesson of the month 1: A rare adverse reaction between flucloxacillin and paracetamol.
Clin Med (Lond)
; 19(2): 127-128, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30872293
ABSTRACT
Flucloxacillin, a beta-lactam antibiotic, is a commonly prescribed antibiotic for the treatment of infections caused by staphylococci and streptococci, most notably Staphylococcus aureus Paracetamol is one of the most dispensed medications by NHS England and is used for the treatment of fever and pain.1 However most doctors are unaware that concurrent use of these drugs can cause a potentially fatal drug interaction due to pyroglutamic acidosis (PGA), also known as 5-oxoprolinaemia. PGA is a rare cause of raised anion gap metabolic acidosis due to disruption of the γ-glutamyl cycle. We report the case of a patient with multiple comorbidities who developed PGA due to coadministration of paracetamol and flucloxacillin.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Floxacilina
/
Erros Inatos do Metabolismo dos Aminoácidos
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Glutationa Sintase
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Acetaminofen
Limite:
Aged80
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Humans
/
Male
Idioma:
En
Revista:
Clin Med (Lond)
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Reino Unido