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Lapachol biotransformation by filamentous fungi yields bioactive quinone derivatives and lapachol-stimulated secondary metabolites.
Barbosa Coitinho, Luciana; Fumagalli, Fernando; da Rosa-Garzon, Nathália Gonsales; da Silva Emery, Flavio; Cabral, Hamilton.
Afiliação
  • Barbosa Coitinho L; a School of Pharmaceutical Sciences of Ribeirao Preto , University of São Paulo , Ribeirão Preto , Brazil.
  • Fumagalli F; a School of Pharmaceutical Sciences of Ribeirao Preto , University of São Paulo , Ribeirão Preto , Brazil.
  • da Rosa-Garzon NG; a School of Pharmaceutical Sciences of Ribeirao Preto , University of São Paulo , Ribeirão Preto , Brazil.
  • da Silva Emery F; a School of Pharmaceutical Sciences of Ribeirao Preto , University of São Paulo , Ribeirão Preto , Brazil.
  • Cabral H; a School of Pharmaceutical Sciences of Ribeirao Preto , University of São Paulo , Ribeirão Preto , Brazil.
Prep Biochem Biotechnol ; 49(5): 459-463, 2019.
Article em En | MEDLINE | ID: mdl-30896339
ABSTRACT
Lapachol is a natural naphthoquinone with a range of biological effects, including anticancer activity. Microbial transformations of lapachol can lead to the formation of new biologically active compounds. In addition, fungi can produce secondary metabolites that are also important for drug discovery. The goal of this study was to evaluate the ability of filamentous fungi to biotransform lapachol into biologically active compounds and identify secondary metabolites produced in the presence of lapachol. Seven out of nine strains of filamentous fungi tested exhibited the ability to biotransform or biodegrade lapachol. The bioactive derivatives norlapachol and isolapachol were identified among biotransformation products. Moreover, lapachol stimulated the production of pyrrolo-[1,2-a] pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl) and phenol-2,4-bis-(1,1-dimethylethyl), secondary metabolites already known to have antimicrobial and antioxidant activities. These results open the perspective of using these strains of filamentous fungi for lapachol biotransformation and efficient production of several biologically active compounds.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Fungos Idioma: En Revista: Prep Biochem Biotechnol Assunto da revista: BIOQUIMICA / BIOTECNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Fungos Idioma: En Revista: Prep Biochem Biotechnol Assunto da revista: BIOQUIMICA / BIOTECNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil