Downregulated microRNA-135a ameliorates rheumatoid arthritis by inactivation of the phosphatidylinositol 3-kinase/AKT signaling pathway via phosphatidylinositol 3-kinase regulatory subunit 2.

Qu, Yuan; Zhang, Yu-Ping; Wu, Jing; Jie, Li-Gang; Deng, Jia-Xin; Zhao, Dong-Bao; Yu, Qing-Hong

Qu, Yuan; Zhang, Yu-Ping; Wu, Jing; Jie, Li-Gang; Deng, Jia-Xin; Zhao, Dong-Bao; Yu, Qing-Hong.

Afiliação

Qu Y; Department of Rheumatology and Clinical Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Zhang YP; Department of Rheumatology and Clinical Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Wu J; Department of Rheumatology and Clinical Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Jie LG; Department of Rheumatology and Clinical Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Deng JX; Department of Rheumatology and Clinical Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Zhao DB; Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Yu QH; Department of Rheumatology and Clinical Immunology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.

J Cell Physiol ; 234(10): 17663-17676, 2019 08.

Article em En | MEDLINE | ID: mdl-30912120

Assuntos

Artrite Reumatoide/genética; Artrite Reumatoide/metabolismo; MicroRNAs/genética; MicroRNAs/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Adulto; Idoso; Apoptose; Artrite Reumatoide/patologia; Pontos de Checagem do Ciclo Celular/genética; Movimento Celular; Proliferação de Células; Células Cultivadas; Regulação para Baixo; Feminino; Fibroblastos/metabolismo; Fibroblastos/patologia; Humanos; Masculino; Pessoa de Meia-Idade; Fosfatidilinositol 3-Quinases/genética; Transdução de Sinais; Membrana Sinovial/metabolismo; Membrana Sinovial/patologia; Regulação para Cima; Adulto Jovem

Palavras-chave

PI3K/AKT signaling pathway; PIK3R2; apoptosis; microRNA-135a; migration; proliferation; rheumatoid arthritis; synovial fibroblasts

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Fosfatidilinositol 3-Quinases / MicroRNAs / Proteínas Proto-Oncogênicas c-akt Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cell Physiol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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