An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation.
J Biomech
; 88: 186-189, 2019 May 09.
Article
em En
| MEDLINE
| ID: mdl-30922612
ABSTRACT
Children randomised in the neonatal period to high frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) in the United Kingdom Oscillation study (UKOS) had superior lung function at 11 to 14â¯years of age. During HFOV, much smaller tidal volumes, but a higher mean airway distending pressure is delivered, hence, a possible explanation for a volume dependent effect on long term lung function could be an increase in inflammation in response to higher tidal volumes and strains. We tested that hypothesis by assessing interleukin-6 (IL-6) and -8 (IL-8) release from A549 alveolar analogue cells following biaxial mechanical strain applied at 0.5â¯Hz occurring during conditions mimicking strain during CMV (5-20% strain) and conditions mimicking strain during HFOV (17.5%⯱â¯2.5% strain) for up to 4â¯h. Cyclic strain of 5-20%, occurring during CMV, increased levels of both IL-6 and IL-8 compared to unstrained controls, while 17.5%⯱â¯2.5% strain, occurring during HFOV, was associated with significantly lower levels of IL-6 (46.31⯱â¯2.66 versus 56.79⯱â¯3.73â¯pg/mL) and IL-8 (1340.2⯱â¯74.9 versus 2522⯱â¯248â¯pg/mL) secretion compared to conditions occurring during CMV at four hours. These results may provide a possible explanation for the superior lung function in 11-14-year-old children who had been supported in the neonatal period by HFOV.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Respiração Artificial
/
Interleucina-8
/
Interleucina-6
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Revista:
J Biomech
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Reino Unido