Decreased miR-325-5p Contributes to Visceral Hypersensitivity Through Post-transcriptional Upregulation of CCL2 in Rat Dorsal Root Ganglia.

Wu, Rui; Zhang, Ping-An; Liu, Xuelian; Zhou, Yuan; Xu, Meijie; Jiang, Xinghong; Yan, Jun; Xu, Guang-Yin

Wu, Rui; Zhang, Ping-An; Liu, Xuelian; Zhou, Yuan; Xu, Meijie; Jiang, Xinghong; Yan, Jun; Xu, Guang-Yin.

Afiliação

Wu R; Center for Translational Medicine, Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, 215600, China.
Zhang PA; Department of Physiology and Neurobiology, Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Liu X; Center for Translational Medicine, Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, 215600, China.
Zhou Y; Department of Physiology and Neurobiology, Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Xu M; Department of Physiology and Neurobiology, Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Jiang X; Department of Physiology and Neurobiology, Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Yan J; Center for Translational Medicine, Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, 215600, China.
Xu GY; Department of Physiology and Neurobiology, Institute of Neuroscience, Soochow University, Suzhou, 215123, China.

Neurosci Bull ; 35(5): 791-801, 2019 Oct.

Article em En | MEDLINE | ID: mdl-30980241

Assuntos

Quimiocina CCL2/biossíntese; Gânglios Espinais/metabolismo; Hiperalgesia/metabolismo; MicroRNAs/biossíntese; Dor Visceral/metabolismo; Animais; Animais Recém-Nascidos; Quimiocina CCL2/genética; Colo/metabolismo; Colo/patologia; Gânglios Espinais/patologia; Hiperalgesia/genética; Hiperalgesia/patologia; Masculino; MicroRNAs/antagonistas & inibidores; MicroRNAs/genética; Ratos; Ratos Sprague-Dawley; Transcrição Gênica/fisiologia; Regulação para Cima/fisiologia; Dor Visceral/genética; Dor Visceral/patologia

Palavras-chave

CCL2; Dorsal root ganglia; Epigenetic regulation; Visceral pain; miRNA-325-5p

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quimiocina CCL2 / MicroRNAs / Dor Visceral / Gânglios Espinais / Hiperalgesia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurosci Bull Assunto da revista: NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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