Transmembrane H+/Cl- cotransport activity of bis(amido)imidazole receptors.
Org Biomol Chem
; 17(18): 4483-4490, 2019 05 08.
Article
em En
| MEDLINE
| ID: mdl-30984952
ABSTRACT
A series of sickle-shaped bis(amido) imidazoles are synthesized for their ion transport studies. Proton-anion binding by the neutral and protonated form of receptors assessed by 1H-NMR titration experiments confirmed better chloride binding by the protonated form of a receptor compared to its neutral form. The transport experiments across unimolecular vesicles (by HPTS and lucigenin assays) confirmed the H+/Cl- symport process under the applied pH gradient conditions. The transporter also allows anion antiport as evident from the studies under symmetrical pH conditions. The ionophoric activity by the mobile carrier mechanism is proved by the U-tube experiment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Índia