Prof. Arnost Gutmann 16. 7. 1910 - 6. 8. 1977.
Physiol Res
; 66(5): xiii-xvi, 2017 Nov 24.
Article
em En
| MEDLINE
| ID: mdl-30993997
ABSTRACT
The multitalented neuropeptide galanin was first discovered 30 years ago but initially no biologic activity was found. Further research studies discovered the presence of galanin in the brain and some peripheral tissues, and galanin was identified as a modulator of neurotransmission in the central and peripheral nervous system. Over the last decade there were performed very intensive studies of the neuronal actions and also of nonneuronal actions of galanin. Other galanin family peptides have been described, namely galanin, galanin-like peptide, galanin-message associated peptide and alarin. The effect of these peptides is mediated through three galanin receptors subtypes, GalR1, GalR2 and GalR3 belonging to G protein coupled receptors, and signaling via multiple transduction pathways, including inhibition of cyclic AMP/protein kinase A (GalR1, GalR3) and stimulation of phospholipase C (GalR2). This also explains why one specific molecule of galanin can be responsible for different roles in different tissues. The present review summarizes the information currently available on the relationship between the galaninergic system and known pathological states. The research of novel galanin receptor specific agonists and antagonists is also very promising for its future role in pharmacological treatment. The galaninergic system is important target for current and future biomedical research.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fisiologia
/
Músculo Esquelético
/
Pesquisa Biomédica
/
Doenças Neuromusculares
/
Junção Neuromuscular
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Physiol Res
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
República Tcheca