Nerve growth factor gene therapy improves bone marrow sensory innervation and nociceptor-mediated stem cell release in a mouse model of type 1 diabetes with limb ischaemia.

Dang, Zexu; Avolio, Elisa; Albertario, Ambra; Sala-Newby, Graciela B; Thomas, Anita C; Wang, Nianhong; Emanueli, Costanza; Madeddu, Paolo

Dang, Zexu; Avolio, Elisa; Albertario, Ambra; Sala-Newby, Graciela B; Thomas, Anita C; Wang, Nianhong; Emanueli, Costanza; Madeddu, Paolo.

Afiliação

Dang Z; Experimental Cardiovascular Medicine, Faculty of Translational Health Sciences, Bristol Medical School, University of Bristol, Upper Maudlin Street, Bristol, BS2 8HW, UK.
Avolio E; Experimental Cardiovascular Medicine, Faculty of Translational Health Sciences, Bristol Medical School, University of Bristol, Upper Maudlin Street, Bristol, BS2 8HW, UK.
Albertario A; Experimental Cardiovascular Medicine, Faculty of Translational Health Sciences, Bristol Medical School, University of Bristol, Upper Maudlin Street, Bristol, BS2 8HW, UK.
Sala-Newby GB; Experimental Cardiovascular Medicine, Faculty of Translational Health Sciences, Bristol Medical School, University of Bristol, Upper Maudlin Street, Bristol, BS2 8HW, UK.
Thomas AC; Experimental Cardiovascular Medicine, Faculty of Translational Health Sciences, Bristol Medical School, University of Bristol, Upper Maudlin Street, Bristol, BS2 8HW, UK.
Wang N; Experimental Cardiovascular Medicine, Faculty of Translational Health Sciences, Bristol Medical School, University of Bristol, Upper Maudlin Street, Bristol, BS2 8HW, UK.
Emanueli C; Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Pudong, Shanghai, China.
Madeddu P; National Heart and Lung Institute, Imperial College London, London, UK.

Diabetologia ; 62(7): 1297-1311, 2019 07.

Article em En | MEDLINE | ID: mdl-31016359

Assuntos

Diabetes Mellitus Tipo 1/terapia; Terapia Genética/métodos; Fator de Crescimento Neural/metabolismo; Células Receptoras Sensoriais/citologia; Células-Tronco/citologia; Animais; Medula Óssea; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/terapia; Diabetes Mellitus Tipo 1/metabolismo; Imuno-Histoquímica; Isquemia/terapia; Masculino; Camundongos; Células Receptoras Sensoriais/metabolismo; Células-Tronco/metabolismo

Palavras-chave

Bone marrow; Bone marrow stem cells; Gene therapy; Nerve growth factor; Nociceptor; PC12 cells; Peripheral ischaemia; Sensory neuropathy; Substance P; Type 1 diabetes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Receptoras Sensoriais / Células-Tronco / Terapia Genética / Fator de Crescimento Neural / Diabetes Mellitus Tipo 1 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Diabetologia Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

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