GaCl3-Catalyzed C-H Cyanation of Indoles with N-Cyanosuccinimide.
J Org Chem
; 84(10): 6199-6206, 2019 May 17.
Article
em En
| MEDLINE
| ID: mdl-31016983
ABSTRACT
An efficient GaCl3-catalyzed direct cyanation of indoles and pyrroles using bench-stable electrophilic cyanating agent N-cyanosuccinimide was achieved and afforded 3-cyanoindoles and 2-cyanopyrroles in good yields and excellent regioselectivities. Notably, this protocol exhibited high reactivity for unprotected indoles and was applicable to a broad range of indole and pyrrole substrates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2019
Tipo de documento:
Article