Abnormalities of lymphocyte subsets and anti-LAV/HTLV-III status in Greek hemophiliacs.
AIDS Res
; 2(4): 271-7, 1986.
Article
em En
| MEDLINE
| ID: mdl-3101712
ABSTRACT
Peripheral blood lymphocyte subsets and the incidence of LAV/HTLV-III antibodies were studied in 63 patients with hemophilia A who had been transfused with a low dose regimen of commercial (U.S.A.) factor VIII concentrates. Five patients with hemophilia B were also included in this study. In hemophilia A patients a significant reduction in the percentage and absolute numbers of T4+ cells and of the T4/T8 ratio and a significant increase in the percentage of T8+ and Leu-7+ cells were observed. These abnormalities were independent of the presence of anti-LAV/HTLV-III. In hemophilia B patients a significant increase of T8+ cells and a decrease of T4/T8 ratio was noted while the percentage of Leu-7+ cells was normal. A significant negative correlation of F VIII units transfused and T4/T8 ratio was seen only in LAV/HTLV (-) patients, suggesting that F VIII per se could cause immunodysregulation. Seropositive patients were found to have consumed a larger amount of F VIII units than seronegative patients during the period 1980-1984 (p less than 0.005).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator VIII
/
Linfócitos T
/
HIV
/
Hemofilia A
/
Anticorpos Antivirais
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
AIDS Res
Ano de publicação:
1986
Tipo de documento:
Article