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Nonclassical Monocytes in Health and Disease.
Narasimhan, Prakash Babu; Marcovecchio, Paola; Hamers, Anouk A J; Hedrick, Catherine C.
Afiliação
  • Narasimhan PB; Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA; email: prakash@lji.org , pmarco@lji.org , anouk@lji.org , hedrick@lji.org.
  • Marcovecchio P; Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA; email: prakash@lji.org , pmarco@lji.org , anouk@lji.org , hedrick@lji.org.
  • Hamers AAJ; Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA; email: prakash@lji.org , pmarco@lji.org , anouk@lji.org , hedrick@lji.org.
  • Hedrick CC; Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA; email: prakash@lji.org , pmarco@lji.org , anouk@lji.org , hedrick@lji.org.
Annu Rev Immunol ; 37: 439-456, 2019 04 26.
Article em En | MEDLINE | ID: mdl-31026415
Monocytes are innate blood cells that maintain vascular homeostasis and are early responders to pathogens in acute infections. There are three well-characterized classes of monocytes: classical (CD14+CD16- in humans and Ly6Chi in mice), intermediate (CD14+CD16+ in humans and Ly6C+Treml4+ in mice), and nonclassical (CD14-CD16+ in humans and Ly6Clo in mice). Classical monocytes are critical for the initial inflammatory response. Classical monocytes can differentiate into macrophages in tissue and can contribute to chronic disease. Nonclassical monocytes have been widely viewed as anti-inflammatory, as they maintain vascular homeostasis. They are a first line of defense in recognition and clearance of pathogens. However, their roles in chronic disease are less clear. They have been shown to be protective as well as positively associated with disease burden. This review focuses on the state of the monocyte biology field and the functions of monocytes, particularly nonclassical monocytes, in health and disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Vasos Sanguíneos / Monócitos / Aterosclerose / Infarto do Miocárdio Limite: Animals / Humans Idioma: En Revista: Annu Rev Immunol Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Vasos Sanguíneos / Monócitos / Aterosclerose / Infarto do Miocárdio Limite: Animals / Humans Idioma: En Revista: Annu Rev Immunol Ano de publicação: 2019 Tipo de documento: Article