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Lipidomic Analysis Reveals Serum Alteration of Plasmalogens in Patients Infected With ZIKA Virus.
Queiroz, Adriano; Pinto, Isabella Fernanda Dantas; Lima, Maricélia; Giovanetti, Marta; de Jesus, Jaqueline Goes; Xavier, Joilson; Barreto, Fernanda Khouri; Canuto, Gisele André Baptista; do Amaral, Helineide Ramos; de Filippis, Ana Maria Bispo; Mascarenhas, Denise Lima; Falcão, Melissa Barreto; Santos, Normeide Pedreira; Azevedo, Vasco Ariston de Carvalho; Yoshinaga, Marcos Yukio; Miyamoto, Sayuri; Alcantara, Luiz Carlos Junior.
Afiliação
  • Queiroz A; Laboratório de Patologia Experimental, Instituto Gonçalo Moniz, Salvador, Brazil.
  • Pinto IFD; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
  • Lima M; Departamento de Saúde, Universidade Estadual de Feira de Santana, Feira de Santana, Brazil.
  • Giovanetti M; Laboratório de Patologia Experimental, Instituto Gonçalo Moniz, Salvador, Brazil.
  • de Jesus JG; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Xavier J; Laboratório de Patologia Experimental, Instituto Gonçalo Moniz, Salvador, Brazil.
  • Barreto FK; Laboratório de Patologia Experimental, Instituto Gonçalo Moniz, Salvador, Brazil.
  • Canuto GAB; Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista, Brazil.
  • do Amaral HR; Departamento de Química Analítica, Instituto de Química, Universidade Federal da Bahia, Salvador, Brazil.
  • de Filippis AMB; Núcleo de Pesquisa em Vigilância da Saúde, Universidade Estadual de Feira de Santana, Feira de Santana, Brazil.
  • Mascarenhas DL; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Falcão MB; Secretaria Municipal de Saúde do Município de Feira de Santana, Feira de Santana, Brazil.
  • Santos NP; Secretaria Municipal de Saúde do Município de Feira de Santana, Feira de Santana, Brazil.
  • Azevedo VAC; Secretaria Municipal de Saúde do Município de Feira de Santana, Feira de Santana, Brazil.
  • Yoshinaga MY; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Miyamoto S; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
  • Alcantara LCJ; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Front Microbiol ; 10: 753, 2019.
Article em En | MEDLINE | ID: mdl-31031729
Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the Flavivirus genus of the Flaviviridae family. Since the large outbreaks in French Polynesia in 2013-2014 and in Brazil in 2015, ZIKV has been considered a new public health threat. Similar to other related flavivirus, ZIKV is associated with mild and self-limiting symptoms such as rash, pruritus, prostration, headache, arthralgia, myalgia, conjunctivitis, lower back pain and, when present, a short-term low grade fever. In addition, ZIKV has been implicated in neurological complications such as neonatal microcephaly and Guillain-Barré syndrome in adults. Herein, serum lipidomic analysis was used to identify possible alterations in lipid metabolism triggered by ZIKV infection. Patients who presented virus-like symptoms such as fever, arthralgia, headache, exanthema, myalgia and pruritus were selected as the control group. Our study reveals increased levels of several phosphatidylethanolamine (PE) lipid species in the serum of ZIKV patients, the majority of them plasmenyl-phosphatidylethanolamine (pPE) (or plasmalogens) linked to polyunsaturated fatty acids. Constituting up to 20% of total phospholipids in humans, plasmalogens linked to polyunsaturated fatty acids are particularly enriched in neural membranes of the brain. The biosynthesis of plasmalogens requires functional peroxisomes, which are important sites for viral replication, including ZIKV. Thus, increased levels of plasmalogens in serum of ZIKV infected subjects suggest a link between ZIKV life cycle and peroxisomes. Our data provide important insights into specific host cellular lipids that are likely associated with ZIKV replication and may serve as platform for antiviral strategy against ZIKV.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Microbiol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Microbiol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil