Letrozole induces worse hippocampal synaptic and dendritic changes and spatial memory impairment than ovariectomy in adult female mice.

Liu, Mengying; Xing, Fangzhou; Bian, Chen; Zhao, Yangang; Zhao, Jikai; Liu, Yan; Zhang, Jiqiang

Liu, Mengying; Xing, Fangzhou; Bian, Chen; Zhao, Yangang; Zhao, Jikai; Liu, Yan; Zhang, Jiqiang.

Afiliação

Liu M; Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing, 400038, China.
Xing F; School of Life Sciences, Southwest University, Chongqing, 400715, China.
Bian C; Department of Military Psychology, College of Psychology, Third Military Medical University, Chongqing, 400038, China.
Zhao Y; Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing, 400038, China.
Zhao J; Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing, 400038, China.
Liu Y; School of Life Sciences, Southwest University, Chongqing, 400715, China. Electronic address: zhangjqtmmu@yahoo.com.
Zhang J; Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing, 400038, China. Electronic address: liuyan@swu.edu.cn.

Neurosci Lett ; 706: 61-67, 2019 07 27.

Article em En | MEDLINE | ID: mdl-31077740

Assuntos

Inibidores da Aromatase/farmacologia; Dendritos/efeitos dos fármacos; Hipocampo/efeitos dos fármacos; Letrozol/farmacologia; Memória Espacial/efeitos dos fármacos; Sinapses/efeitos dos fármacos; Actinas/metabolismo; Animais; Dendritos/metabolismo; Feminino; Hipocampo/metabolismo; Camundongos; Plasticidade Neuronal/efeitos dos fármacos; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Coativador 1 de Receptor Nuclear/metabolismo; Ovariectomia; Aprendizagem Espacial/efeitos dos fármacos; Sinapses/metabolismo

Palavras-chave

Actin polymerization; Aromatase; Letrozole; Ovariectomy; Rictor; Spatial memory

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinapses / Dendritos / Inibidores da Aromatase / Memória Espacial / Letrozol / Hipocampo Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google