Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging.
J Exp Med
; 149(2): 416-23, 1979 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-310864
ABSTRACT
The rate of capping and shedding of cross-linked surface immunoglobulins (SIg) was slower in old Lewis rats (greater than 24 mo) than in young Lewis rats (3-4 mo). Analysis of spleen cell populations with the fluorescence-activated cell sorter indicated that with aging there was a loss of cells with a high density of SIg. Cells with the highest density of SIg capped and shed cross-linked SIg faster than cells with a low density of SIg. The alteration in density of SIg may account for the difference in capping kinetics. Colchicine treatment increased the rate of capping of lymphocytes from young animals, but had no effect on the capping kinetics of lymphocytes from old animals.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Linfócitos B
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Receptores de Antígenos de Linfócitos B
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Capeamento Imunológico
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1979
Tipo de documento:
Article