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Fertility Outcome After Renal Transplantation: A Single-Center Experience.
Yaprak, M; Dogru, V; Sanhal, C Y; Avanaz, A; Erman, M.
Afiliação
  • Yaprak M; Department of General Surgery, Akdeniz University Hospital, Antalya, Turkey. Electronic address: muhittin.yaprak@gmail.com.
  • Dogru V; Department of General Surgery, Akdeniz University Hospital, Antalya, Turkey.
  • Sanhal CY; Department of Obstetrics and Gynecology, Akdeniz University Hospital, Antalya, Turkey.
  • Avanaz A; Department of General Surgery, Akdeniz University Hospital, Antalya, Turkey; Prof. Dr. A. Ilhan Özdemir Education and Research Hospital, Giresun University, Giresun, Turkey.
  • Erman M; Department of Obstetrics and Gynecology, Akdeniz University Hospital, Antalya, Turkey.
Transplant Proc ; 51(4): 1108-1111, 2019 May.
Article em En | MEDLINE | ID: mdl-31101181
ABSTRACT

BACKGROUND:

Women suffering from kidney disease are more prone to fertility problems, due to uremia. Fortunately, their fertility rate increases dramatically after renal transplantation. This study analyzes the predictors/risk factors of successful pregnancy with live birth outcome while presenting an overview of the 7-year experience of a single center.

METHODS:

This retrospective cohort study includes 239 women of reproductive age (18-40 years) who underwent renal transplantation in a tertiary Turkish clinic between October 1, 2011, and August 24, 2017. The subjects were invited to take part in a survey questioning their obstetric characteristics and they were assessed in 2 groups fertile and infertile. Multivariable linear regression analysis was conducted to determine the predictors of a successful pregnancy.

RESULTS:

Thirty-five 35 patients wished to become pregnant 12 got pregnant spontaneously, while 21 failed to become pregnant (spontaneously). The mean age of the patients at the survey was 34 ± 7. Regular menstrual cycles after renal transplantation, tacrolimus-mycophenolate mofetil maintenance protocol, and age at transplantation were found to be predictors of spontaneous pregnancy. The duration of peritoneal dialysis was significantly longer in the infertile group (48 vs 12 months).

CONCLUSION:

End-stage renal disease's negative impacts, including menstrual abnormality and fertility problems, can be overcome by successful kidney transplantation with appropriate immunosuppression. Minimizing the duration of peritoneal dialysis, particularly in patients who desire future fertility, may be accepted as a logical management strategy.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resultado da Gravidez / Transplante de Rim / Taxa de Gravidez / Fertilidade Tipo de estudo: Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Transplant Proc Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resultado da Gravidez / Transplante de Rim / Taxa de Gravidez / Fertilidade Tipo de estudo: Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Transplant Proc Ano de publicação: 2019 Tipo de documento: Article