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Relationship Between Seizure Frequency and Functional Abnormalities in Limbic Network of Medial Temporal Lobe Epilepsy.
Jo, Hang Joon; Kenney-Jung, Daniel L; Balzekas, Irena; Welker, Kirk M; Jones, David T; Croarkin, Paul E; Benarroch, Eduardo E; Worrell, Gregory A.
Afiliação
  • Jo HJ; Department of Neurology, Mayo Clinic, Rochester, MN, United States.
  • Kenney-Jung DL; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
  • Balzekas I; Department of Radiology, Mayo Clinic, Rochester, MN, United States.
  • Welker KM; Department of Neurology, Mayo Clinic, Rochester, MN, United States.
  • Jones DT; Department of Neurology, Mayo Clinic, Rochester, MN, United States.
  • Croarkin PE; Department of Radiology, Mayo Clinic, Rochester, MN, United States.
  • Benarroch EE; Department of Neurology, Mayo Clinic, Rochester, MN, United States.
  • Worrell GA; Department of Radiology, Mayo Clinic, Rochester, MN, United States.
Front Neurol ; 10: 488, 2019.
Article em En | MEDLINE | ID: mdl-31133978
Background: We compared resting-state functional connectivity (RSFC) among limbic and temporal lobe regions between patients with medial temporal lobe epilepsy (mTLE) and healthy control subjects to identify imaging evidence of functional networks related to seizure frequency, age of seizure onset, and duration of epilepsy. Methods: Twelve patients with drug-resistant, unilateral medial temporal lobe epilepsy and 12 healthy control subjects matched for age, sex, and handedness participated in the imaging experiments. We used network-based statistics to compare functional connectivity graphs in patients with mTLE and healthy controls to investigate the relationship between functional connectivity abnormalities and seizure frequency. Results: Among mTLE patients, we found functional network abnormalities throughout the limbic system, but primarily in the hemisphere ipsilateral to the seizure focus. The RSFCs between ipsilateral hypothalamus and ventral anterior cingulate cortex and between ipsilateral subiculum and contralateral posterior cingulate cortex were highly correlated with seizure frequency. Discussion: These findings suggest that in mTLE, changes in limbic networks ipsilateral to the epileptic focus are common. The pathological changes in connectivity between cingulate cortex, hypothalamus and subiculum ipsilateral to the seizure focus were correlated with increased seizure frequency.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Neurol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Neurol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos