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Echocardiographic Abnormalities and Determinants of 1-Month Outcome of Stroke Among West Africans in the SIREN Study.
Adeoye, Abiodun M; Ovbiagele, Bruce; Akinyemi, Joshua O; Ogah, Okechukwu S; Akinyemi, Rufus; Gebregziabher, Mulugeta; Wahab, Kolawole; Fakunle, Adekunle G; Akintunde, Adeseye; Adebayo, Oladimeji; Aje, Akinyemi; Tiwari, Hemant K; Arnett, Donna; Agyekum, Francis; Appiah, Lambert T; Amusa, Ganiyu; Olunuga, Taiwo O; Onoja, Akpa; Sarfo, Fred S; Akpalu, Albert; Jenkins, Carolyn; Lackland, Daniel; Owolabi, Lukman; Komolafe, Morenikeji; Faniyan, Moyinoluwalogo M; Arulogun, Oyedunni; Obiako, Reginald; Owolabi, Mayowa.
Afiliação
  • Adeoye AM; 1 Center for Genomic and Precision Medicine University of Ibadan Ibadan Nigeria.
  • Ovbiagele B; 2 Department of Neurology University of California San Francisco CA.
  • Akinyemi JO; 3 University of Ibadan Ibadan Nigeria.
  • Ogah OS; 3 University of Ibadan Ibadan Nigeria.
  • Akinyemi R; 4 Federal Medical Centre Abeokuta Nigeria.
  • Gebregziabher M; 5 Medical University of South Carolina Charleston SC.
  • Wahab K; 6 University of Ilorin Ilorin Nigeria.
  • Fakunle AG; 3 University of Ibadan Ibadan Nigeria.
  • Akintunde A; 7 Ladoke Akintola University of Technology Ogbomoso Nigeria.
  • Adebayo O; 8 University College Hospital Ibadan Nigeria.
  • Aje A; 8 University College Hospital Ibadan Nigeria.
  • Tiwari HK; 9 University of Alabama at Birmingham Birmingham AL.
  • Arnett D; 10 University of Kentucky at Lexington KY.
  • Agyekum F; 11 University of Ghana Medical School Accra Ghana.
  • Appiah LT; 12 Komfo Anokye Teaching Hospital Kumasi Ghana.
  • Amusa G; 13 Jos University Teaching Hospital Jos Nigeria.
  • Olunuga TO; 4 Federal Medical Centre Abeokuta Nigeria.
  • Onoja A; 3 University of Ibadan Ibadan Nigeria.
  • Sarfo FS; 12 Komfo Anokye Teaching Hospital Kumasi Ghana.
  • Akpalu A; 11 University of Ghana Medical School Accra Ghana.
  • Jenkins C; 5 Medical University of South Carolina Charleston SC.
  • Lackland D; 5 Medical University of South Carolina Charleston SC.
  • Owolabi L; 14 Aminu Kano Teaching Hospital Kano Nigeria.
  • Komolafe M; 15 Obafemi Awolowo University Teaching Hospital Ile-Ife Nigeria.
  • Faniyan MM; 3 University of Ibadan Ibadan Nigeria.
  • Arulogun O; 3 University of Ibadan Ibadan Nigeria.
  • Obiako R; 16 Ahmadu Bello University Zaria Nigeria.
  • Owolabi M; 1 Center for Genomic and Precision Medicine University of Ibadan Ibadan Nigeria.
J Am Heart Assoc ; 8(11): e010814, 2019 06 04.
Article em En | MEDLINE | ID: mdl-31142178
Background Little is known about the relationship between echocardiographic abnormalities and outcome among patients with acute stroke. We investigated the pattern and association of baseline echocardiographic variables with 1-month disability and mortality among patients with stroke in the SIREN (Stroke Investigative Research and Education Network) study. Methods and Results We enrolled and followed up consecutive 1020 adult patients with acute stroke with baseline transthoracic echocardiography from west Africa. To explore the relationship between echocardiographic variables and 1-month disability (using modified Rankin scale >3) and fatality, regression models were fitted. Relative risks were computed with 95% CIs. The participants comprised 60% men with a mean age of 59.2±14.6 years. Ischemic stroke was associated with smaller aortic root diameter (30.2 versus 32.5, P=0.018) and septal (16.8 versus 19.1, P<0.001) and posterior wall thickness at systole (18.9 versus 21.5, P=0.004). Over 90% of patients with stroke had abnormal left ventricular (LV) geometry with eccentric hypertrophy predominating (56.1%). Of 13 candidate variables investigated, only baseline abnormal LV geometry (concentric hypertrophy) was weakly associated with 1-month disability (unadjusted relative risk, 1.80; 95% CI , 0.97-5.73). Severe LV systolic dysfunction was significantly associated with increased 1-month mortality (unadjusted relative risk, 3.05; 95% CI , 1.36-6.83). Conclusions Nine of 10 patients with acute stroke had abnormal LV geometry and a third had systolic dysfunction. Severe LV systolic dysfunction was significantly associated with 1 month mortality. Larger studies are required to establish the independent effect and unravel predictive accuracy of this association.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ecocardiografia / Função Ventricular Esquerda / Hipertrofia Ventricular Esquerda / Disfunção Ventricular Esquerda / Remodelação Ventricular / Acidente Vascular Cerebral Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Revista: J Am Heart Assoc Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ecocardiografia / Função Ventricular Esquerda / Hipertrofia Ventricular Esquerda / Disfunção Ventricular Esquerda / Remodelação Ventricular / Acidente Vascular Cerebral Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Revista: J Am Heart Assoc Ano de publicação: 2019 Tipo de documento: Article