Increase of IgA-bearing lymphocytes in peripheral blood from patients with IgA nephropathy.
Am J Clin Pathol
; 71(2): 158-60, 1979 Feb.
Article
em En
| MEDLINE
| ID: mdl-311581
ABSTRACT
Aberration of IgA-bearing B lymphocytes in patients with IgA nephropathy has been investigated. Twelve patients with IgA nephropathy demonstrated a marked increase of IgA-bearing lymphocytes in peripheral blood, while ten patients with chronic proliferative glomerulonephritis without mesangial deposition of IgA showed normal amounts of IgA-bearing lymphocytes. The increase of IgA-bearing lymphocytes reflected that of IgA-producing lymphocytes, since lymphocytes obtained from patients with IgA nephropathy restored a high percentage of IgA-bearing cells in vitro after treatment with trypsin. Quantitation of IgA-bearing lymphocytes in peripheral blood is a useful method for screening of patients with IgA nephropathy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina A
/
Linfócitos B
/
Linfócitos T
/
Glomerulonefrite
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Am J Clin Pathol
Ano de publicação:
1979
Tipo de documento:
Article