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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Farnaby, William; Koegl, Manfred; Roy, Michael J; Whitworth, Claire; Diers, Emelyne; Trainor, Nicole; Zollman, David; Steurer, Steffen; Karolyi-Oezguer, Jale; Riedmueller, Carina; Gmaschitz, Teresa; Wachter, Johannes; Dank, Christian; Galant, Michael; Sharps, Bernadette; Rumpel, Klaus; Traxler, Elisabeth; Gerstberger, Thomas; Schnitzer, Renate; Petermann, Oliver; Greb, Peter; Weinstabl, Harald; Bader, Gerd; Zoephel, Andreas; Weiss-Puxbaum, Alexander; Ehrenhöfer-Wölfer, Katharina; Wöhrle, Simon; Boehmelt, Guido; Rinnenthal, Joerg; Arnhof, Heribert; Wiechens, Nicola; Wu, Meng-Ying; Owen-Hughes, Tom; Ettmayer, Peter; Pearson, Mark; McConnell, Darryl B; Ciulli, Alessio.
Afiliação
  • Farnaby W; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.
  • Koegl M; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Roy MJ; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.
  • Whitworth C; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.
  • Diers E; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.
  • Trainor N; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.
  • Zollman D; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.
  • Steurer S; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Karolyi-Oezguer J; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Riedmueller C; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Gmaschitz T; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Wachter J; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Dank C; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Galant M; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Sharps B; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Rumpel K; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Traxler E; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Gerstberger T; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Schnitzer R; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Petermann O; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Greb P; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Weinstabl H; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Bader G; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Zoephel A; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Weiss-Puxbaum A; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Ehrenhöfer-Wölfer K; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Wöhrle S; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Boehmelt G; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Rinnenthal J; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Arnhof H; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Wiechens N; Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, UK.
  • Wu MY; Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, UK.
  • Owen-Hughes T; Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, UK.
  • Ettmayer P; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • Pearson M; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.
  • McConnell DB; Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria. darryl.mcconnell@boehringer-ingelheim.com.
  • Ciulli A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK. a.ciulli@dundee.ac.uk.
Nat Chem Biol ; 15(7): 672-680, 2019 07.
Article em En | MEDLINE | ID: mdl-31178587
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Leucemia Mieloide Aguda / Montagem e Desmontagem da Cromatina / Proteínas de Ligação a DNA Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Leucemia Mieloide Aguda / Montagem e Desmontagem da Cromatina / Proteínas de Ligação a DNA Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido