[Case of Hyperammonemia Induced by High-Dose Fluorouracil].
Gan To Kagaku Ryoho
; 46(Suppl 1): 147-149, 2019 May.
Article
em Ja
| MEDLINE
| ID: mdl-31189842
ABSTRACT
A case of hyperammonemia induced by chemotherapy, including high-dose fluorouracil(5-FU), for advanced unresectable large intestinal cancer has been reported. This case involved an 81-year-old female who was diagnosed with pT4bcN2M1 (multiple hepatic metastases; stage â
£; KRAS mutant)after emergency surgery for sigmoid colon cancer and diffuse peritonitis. Post-operation, the 4 courses of mFOLFOX6 plus Bmab therapy was started for advanced unresectable recurrent large intestinal cancer; 48 hours later, she developed consciousness disorder(JCS â
¢-300). The disorder promptly disappeared after discontinuation of high-dose 5-FU. Because high-dose 5-FU was inferred to be the main cause of hyperammonemia, XELOX plus Bmab therapy was started as a post-treatment. She did not develop hyperammonemia; therefore, 8 courses were administered. The patient is being followed-up now.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo Sigmoide
/
Hiperamonemia
/
Fluoruracila
/
Neoplasias Hepáticas
Limite:
Aged80
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Female
/
Humans
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Ano de publicação:
2019
Tipo de documento:
Article