Influence of subliminal intragastric fatty acid infusion on subjective and physiological responses to positive emotion induction in healthy women: A randomized trial.
Psychoneuroendocrinology
; 108: 43-52, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31226660
ABSTRACT
BACKGROUND:
Subliminal intragastric fatty acid infusion attenuates subjective and brain responses to negative emotion induction. However, the underlying gut-brain signaling mechanisms remain unclear, and it is unknown whether such effect equally applies to positive emotion.OBJECTIVE:
We aimed to investigate the interaction between fatty acid-induced gut-brain signaling and subjective responses to positive emotion, and the potential mediational role of gastrointestinal (GI) hormones.DESIGN:
Twelve fasting healthy women underwent intragastric infusion of 2.5â¯g lauric acid or saline, after which either positive or neutral emotion was induced for 30â¯min, in 4 separate visits. Appetite-related sensations, subjective emotional state, and GI hormones were measured at baseline and every 10â¯min after infusion. Heart rate variability was measured at baseline and at tâ¯=â¯20-30â¯min to quantify vagal tone (root mean square of successive differences, RMSSD), and sympathovagal balance (low frequency to high frequency ratio, LF/HF).RESULTS:
Fatty acid infusion did not influence appetite-related sensations (as expected), nor emotional state ratings (contrary to expectations). As anticipated, fatty acid stimulated release of CCK at tâ¯=â¯20-40â¯min (pâ¯<â¯0.001), and GLP1 at tâ¯=â¯30-40â¯min (pâ¯<â¯0.001), but not PYY. Interestingly, positive emotion induction suppressed plasma octanoylated ghrelin at tâ¯=â¯20-40â¯min (pâ¯=â¯0.020). Further, both positive emotion and fatty acid attenuated RMSSD (pâ¯=â¯0.012 & 0.0073, respectively). Positive emotion attenuated LF/HF after fatty acid (pâ¯=â¯0.0006), but raised LF/HF after saline (pâ¯=â¯0.004).CONCLUSIONS:
Subliminal fatty acid did not influence subjective responses to positive emotion induction. However, positive emotion induction suppressed octanoylated ghrelin release. Moreover, both positive emotion and subliminal fatty acid decreased cardiac vagal tone. Further, the fatty acid reversed the effect of positive emotion on sympathovagal balance.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apetite
/
Emoções
/
Ácidos Láuricos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Psychoneuroendocrinology
Ano de publicação:
2019
Tipo de documento:
Article