Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension.

Gomez-Puerto, Maria Catalina; van Zuijen, Iris; Huang, Christopher Jz; Szulcek, Robert; Pan, Xiaoke; van Dinther, Maarten Ah; Kurakula, Kondababu; Wiesmeijer, Catharina C; Goumans, Marie-Jose; Bogaard, Harm-Jan; Morrell, Nicholas W; Rana, Amer Ahmed; Ten Dijke, Peter

Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension.

Gomez-Puerto, Maria Catalina; van Zuijen, Iris; Huang, Christopher Jz; Szulcek, Robert; Pan, Xiaoke; van Dinther, Maarten Ah; Kurakula, Kondababu; Wiesmeijer, Catharina C; Goumans, Marie-Jose; Bogaard, Harm-Jan; Morrell, Nicholas W; Rana, Amer Ahmed; Ten Dijke, Peter.

Afiliação

Gomez-Puerto MC; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
van Zuijen I; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Huang CJ; Department of Medicine, University of Cambridge, Cambridge, UK.
Szulcek R; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Pan X; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
van Dinther MA; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Kurakula K; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Wiesmeijer CC; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Goumans MJ; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Bogaard HJ; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Morrell NW; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Rana AA; Department of Medicine, University of Cambridge, Cambridge, UK.
Ten Dijke P; Department of Medicine, University of Cambridge, Cambridge, UK.

J Pathol ; 249(3): 356-367, 2019 11.

Article em En | MEDLINE | ID: mdl-31257577

Assuntos

Autofagia; Receptores de Proteínas Morfogenéticas Ósseas Tipo II/metabolismo; Células Endoteliais/metabolismo; Músculo Liso Vascular/metabolismo; Miócitos de Músculo Liso/metabolismo; Hipertensão Arterial Pulmonar/metabolismo; Adulto; Idoso; Idoso de 80 Anos ou mais; Animais; Pressão Arterial; Receptores de Proteínas Morfogenéticas Ósseas Tipo II/genética; Linhagem Celular; Citocinas/metabolismo; Modelos Animais de Doenças; Células Endoteliais/patologia; Feminino; Heterozigoto; Humanos; Mediadores da Inflamação/metabolismo; Lisossomos/metabolismo; Lisossomos/patologia; Masculino; Proteínas Associadas aos Microtúbulos/metabolismo; Pessoa de Meia-Idade; Músculo Liso Vascular/patologia; Músculo Liso Vascular/fisiopatologia; Miócitos de Músculo Liso/patologia; Proteólise; Hipertensão Arterial Pulmonar/patologia; Hipertensão Arterial Pulmonar/fisiopatologia; Artéria Pulmonar/metabolismo; Artéria Pulmonar/patologia; Artéria Pulmonar/fisiopatologia; Ratos; Transdução de Sinais; Adulto Jovem

Palavras-chave

BMPR2; BMPR2+/− iPSC-ECs; autophagy; human pulmonary artery endothelial cells (PAECs); human pulmonary artery smooth muscle cells (PASMCs); inflammation; pulmonary arterial hypertension (PAH)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Miócitos de Músculo Liso / Células Endoteliais / Receptores de Proteínas Morfogenéticas Ósseas Tipo II / Hipertensão Arterial Pulmonar / Músculo Liso Vascular Tipo de estudo: Prognostic_studies Limite: Aged80 Idioma: En Revista: J Pathol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda

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