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Anthraquinone-Based Specialized Metabolites from Rhizomes of Bulbine natalensis.
Bae, Ji-Yeong; Ali, Zulfiqar; Wang, Yan-Hong; Chittiboyina, Amar G; Zaki, Ahmed A; Viljoen, Alvaro M; Khan, Ikhlas A.
Afiliação
  • Bae JY; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy , University of Mississippi , University , Mississippi 38677 , United States.
  • Ali Z; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy , University of Mississippi , University , Mississippi 38677 , United States.
  • Wang YH; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy , University of Mississippi , University , Mississippi 38677 , United States.
  • Chittiboyina AG; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy , University of Mississippi , University , Mississippi 38677 , United States.
  • Zaki AA; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy , University of Mississippi , University , Mississippi 38677 , United States.
  • Viljoen AM; Department of Pharmaceutical Sciences and SAMRC Herbal Drugs Research Unit , Tshwane University of Technology , Pretoria 0001 , South Africa.
  • Khan IA; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy , University of Mississippi , University , Mississippi 38677 , United States.
J Nat Prod ; 82(7): 1893-1901, 2019 07 26.
Article em En | MEDLINE | ID: mdl-31287681
The rhizomes of Bulbine natalensis furnished six previously unreported anthraquinone derivatives (1-6), together with eight known specialized metabolites. Their structures were determined by interpretation of 1D and 2D NMR and HRESIMS data. The absolute configurations of compounds 1-6 were determined by specific rotation and circular dichroism experiments. The isolated compounds were evaluated for antimicrobial activities, and compound 1 was found to be a moderate inhibitor (IC50 0.02 µM) against methicillin-resistant Staphylococcus aureus (MRSA).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antraquinonas / Rizoma / Asphodelaceae Idioma: En Revista: J Nat Prod Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antraquinonas / Rizoma / Asphodelaceae Idioma: En Revista: J Nat Prod Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos