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AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.
Saline, Maria; Badertscher, Lukas; Wolter, Madita; Lau, Roxanne; Gunnarsson, Anders; Jacso, Tomas; Norris, Tyrrell; Ottmann, Christian; Snijder, Arjan.
Afiliação
  • Saline M; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Badertscher L; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Wolter M; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology and Institute for Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB Eindhoven, The Netherlands.
  • Lau R; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology and Institute for Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB Eindhoven, The Netherlands.
  • Gunnarsson A; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Jacso T; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Norris T; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Ottmann C; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology and Institute for Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB Eindhoven, The Netherlands.
  • Snijder A; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden. Electronic address: arjan.snijder@astrazeneca.com.
J Biol Chem ; 294(35): 13106-13116, 2019 08 30.
Article em En | MEDLINE | ID: mdl-31308176
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas 14-3-3 / Proteínas Proto-Oncogênicas c-akt / Proteínas Quinases Ativadas por AMP / Proteína Forkhead Box O1 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suécia
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas 14-3-3 / Proteínas Proto-Oncogênicas c-akt / Proteínas Quinases Ativadas por AMP / Proteína Forkhead Box O1 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suécia