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Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.
Pegram, Laurel M; Liddle, Jennifer C; Xiao, Yao; Hoh, Maria; Rudolph, Johannes; Iverson, Dylan B; Vigers, Guy P; Smith, Darin; Zhang, Hailong; Wang, Weiru; Moffat, John G; Ahn, Natalie G.
Afiliação
  • Pegram LM; Department of Biochemistry, University of Colorado, Boulder, CO 80305.
  • Liddle JC; Department of Biochemistry, University of Colorado, Boulder, CO 80305.
  • Xiao Y; Department of Biochemistry, University of Colorado, Boulder, CO 80305.
  • Hoh M; Department of Biochemistry, University of Colorado, Boulder, CO 80305.
  • Rudolph J; Department of Biochemistry, University of Colorado, Boulder, CO 80305.
  • Iverson DB; Department of Biochemistry, University of Colorado, Boulder, CO 80305.
  • Vigers GP; Structural Biology Group, Array BioPharma Inc., Boulder, CO 80301.
  • Smith D; Structural Biology Group, Array BioPharma Inc., Boulder, CO 80301.
  • Zhang H; Structural Biology Group, Array BioPharma Inc., Boulder, CO 80301.
  • Wang W; Structural Biology and Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA 94080.
  • Moffat JG; Structural Biology and Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA 94080.
  • Ahn NG; Department of Biochemistry, University of Colorado, Boulder, CO 80305; natalie.ahn@colorado.edu.
Proc Natl Acad Sci U S A ; 116(31): 15463-15468, 2019 07 30.
Article em En | MEDLINE | ID: mdl-31311868
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MAP Quinases Reguladas por Sinal Extracelular / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MAP Quinases Reguladas por Sinal Extracelular / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article