Non cross-linked equine collagen (Salvecoll-E gel) for treatment of complex ano-rectal fistula.
Asian J Surg
; 43(2): 401-404, 2020 Feb.
Article
em En
| MEDLINE
| ID: mdl-31320233
ABSTRACT
BACKGROUND:
Fistula-in-ano is one of the most commonly presenting anorectal diseases. Sphincter sparing treatment options should be considered in patients with complex fistulas. Salvecoll-E gel is a native collagen deantigenated and purified, non-cross-linked equine dermal extract, with an amino acid composition identical to human collagen.METHODS:
The multicentric trial study was a prospective, single-arm observational clinical study with the objective to assess the efficacy of Salvecoll-E gel for anal fistula repair in 70 patients. All patients had undergone preliminary surgical treatment consisting of positioning of a draining loosing seton that was maintained for a period of 4-6 weeks. After seton removal, a gentle debridement and washing of the fistula track was performed. The scar tissue was removed from the internal orifice. Internal opening was covered by a side-to side mucosal suture. Salvecoll-E was injected through the external opening into the fistula track, the external opening it has been opened.RESULTS:
Twelve months after surgery, 55 patients demonstrated a clinically healed fistula (78,5%), 15 patients have a recurrence (21,5%). Most of the recurrences were observed in the first 6 months of treatment (13/15, 86.6%). We don't observe any worsening in CCF score. The results obtained at 1 year certainly seem satisfactory and in line with the best results published in literature using mini-invasive techniques.CONCLUSION:
Salvecoll-E gel is a promising non-invasive technique for conservative treatment of anal fistulas, it's well tolerated by the patients and, in case of recurrence, reinjection or all other known techniques are feasible.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canal Anal
/
Doenças do Ânus
/
Doenças Retais
/
Colágeno
/
Tratamentos com Preservação do Órgão
/
Fístula
Tipo de estudo:
Observational_studies
Limite:
Animals
Idioma:
En
Revista:
Asian J Surg
Ano de publicação:
2020
Tipo de documento:
Article