Ligustrazine Protects Homocysteine-Induced Apoptosis in Human Umbilical Vein Endothelial Cells by Modulating Mitochondrial Dysfunction.

Fan, Xuesong; Wang, Enshi; He, Jianxun; Zhang, Lei; Zeng, Xiaoli; Gui, Yuan; Sun, Qi; Song, Yang; Yuan, Hui

Fan, Xuesong; Wang, Enshi; He, Jianxun; Zhang, Lei; Zeng, Xiaoli; Gui, Yuan; Sun, Qi; Song, Yang; Yuan, Hui.

Afiliação

Fan X; Department of Clinical Laboratory Center, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
Wang E; Center for Pediatric Cardiac Surgery, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
He J; Department of Clinical Laboratory Center, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
Zhang L; Department of Clinical Laboratory Center, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
Zeng X; Department of Clinical Laboratory Center, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
Gui Y; Department of Clinical Laboratory Center, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
Sun Q; Department of Clinical Laboratory Center, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
Song Y; Department of Clinical Laboratory Center, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China.
Yuan H; Department of Clinical Laboratory Center, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China. yuanhuimango@126.com.

J Cardiovasc Transl Res ; 12(6): 591-599, 2019 12.

Article em En | MEDLINE | ID: mdl-31359360

Assuntos

Antioxidantes/farmacologia; Apoptose/efeitos dos fármacos; Homocisteína/toxicidade; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Mitocôndrias/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Pirazinas/farmacologia; Células Cultivadas; Citocromos c/metabolismo; Citoproteção; Células Endoteliais da Veia Umbilical Humana/metabolismo; Células Endoteliais da Veia Umbilical Humana/patologia; Humanos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Mitocôndrias/metabolismo; Mitocôndrias/patologia; Transdução de Sinais

Palavras-chave

Cell apoptosis; Homocysteine; Human umbilical vein endothelial cells (HUVECs); Ligustrazine; Mitochondria dysfunction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazinas / Apoptose / Estresse Oxidativo / Células Endoteliais da Veia Umbilical Humana / Homocisteína / Mitocôndrias / Antioxidantes Limite: Humans Idioma: En Revista: J Cardiovasc Transl Res Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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