Dietary methionine influences therapy in mouse cancer models and alters human metabolism.

Gao, Xia; Sanderson, Sydney M; Dai, Ziwei; Reid, Michael A; Cooper, Daniel E; Lu, Min; Richie, John P; Ciccarella, Amy; Calcagnotto, Ana; Mikhael, Peter G; Mentch, Samantha J; Liu, Juan; Ables, Gene; Kirsch, David G; Hsu, David S; Nichenametla, Sailendra N; Locasale, Jason W

Gao, Xia; Sanderson, Sydney M; Dai, Ziwei; Reid, Michael A; Cooper, Daniel E; Lu, Min; Richie, John P; Ciccarella, Amy; Calcagnotto, Ana; Mikhael, Peter G; Mentch, Samantha J; Liu, Juan; Ables, Gene; Kirsch, David G; Hsu, David S; Nichenametla, Sailendra N; Locasale, Jason W.

Afiliação

Gao X; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Sanderson SM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Dai Z; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Reid MA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Cooper DE; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.
Lu M; Center for Genomics and Computational Biology, Duke University, Durham, NC, USA.
Richie JP; Department of Medical Oncology, Duke University Medical Center, Durham, NC, USA.
Ciccarella A; Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA, USA.
Calcagnotto A; Penn State University Clinical Research Center, State College, PA, USA.
Mikhael PG; Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA, USA.
Mentch SJ; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Liu J; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Ables G; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Kirsch DG; Orentreich Foundation for the Advancement of Science, Cold Spring, NY, USA.
Hsu DS; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Nichenametla SN; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.
Locasale JW; Center for Genomics and Computational Biology, Duke University, Durham, NC, USA.

Nature ; 572(7769): 397-401, 2019 08.

Article em En | MEDLINE | ID: mdl-31367041

Assuntos

Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/metabolismo; Modelos Animais de Doenças; Metabolômica; Metionina/administração & dosagem; Metionina/farmacologia; Sarcoma/tratamento farmacológico; Neoplasias de Tecidos Moles/tratamento farmacológico; Animais; Linhagem Celular Tumoral; Neoplasias Colorretais/genética; Dieta; Feminino; Fluoruracila/farmacologia; Fluoruracila/uso terapêutico; Genes p53; Genes ras; Voluntários Saudáveis; Humanos; Masculino; Metionina/metabolismo; Camundongos; Pessoa de Meia-Idade; Mutação; Estudo de Prova de Conceito; Sarcoma/genética; Sarcoma/metabolismo; Neoplasias de Tecidos Moles/genética; Neoplasias de Tecidos Moles/metabolismo; Enxofre/metabolismo; Resultado do Tratamento

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma / Neoplasias de Tecidos Moles / Neoplasias Colorretais / Modelos Animais de Doenças / Metabolômica / Metionina Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nature Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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