ER-stressed MSC displayed more effective immunomodulation in RA CD4+CXCR5+ICOS+ follicular helper-like T cells through higher PGE2 binding with EP2/EP4.

Wei, Jing; Ouyang, Xunli; Tang, Yawei; Li, Han; Wang, Bing; Ye, Yunshan; Jin, Minli; Al Azab, Mahmoud; Li, Weiping; Li, Xia

ER-stressed MSC displayed more effective immunomodulation in RA CD4⁺CXCR5⁺ICOS⁺ follicular helper-like T cells through higher PGE2 binding with EP2/EP4.

Wei, Jing; Ouyang, Xunli; Tang, Yawei; Li, Han; Wang, Bing; Ye, Yunshan; Jin, Minli; Al Azab, Mahmoud; Li, Weiping; Li, Xia.

Afiliação

Wei J; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China.
Ouyang X; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China.
Tang Y; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China.
Li H; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China.
Wang B; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China.
Ye Y; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China.
Jin M; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China.
Al Azab M; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China.
Li W; Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Liaoning, China.
Li X; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, China.

Mod Rheumatol ; 30(3): 509-516, 2020 May.

Article em En | MEDLINE | ID: mdl-31370727

Assuntos

Artrite Reumatoide/sangue; Linfócitos T CD4-Positivos/imunologia; Estresse do Retículo Endoplasmático; Células-Tronco Mesenquimais/imunologia; Artrite Reumatoide/imunologia; Células Cultivadas; Humanos; Imunomodulação; Proteína Coestimuladora de Linfócitos T Induzíveis/genética; Proteína Coestimuladora de Linfócitos T Induzíveis/metabolismo; Receptores CXCR5/genética; Receptores CXCR5/metabolismo

Palavras-chave

CD4+CXCR5+ICOS+ T cells; endoplasmic reticulum stress; mesenchymal stem cells; prostaglandin E2; rheumatoid arthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Linfócitos T CD4-Positivos / Células-Tronco Mesenquimais / Estresse do Retículo Endoplasmático Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Mod Rheumatol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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