Click chemistry based regioselective one-pot synthesis of coumarin-3-yl-methyl-1,2,3-triazolyl-1,2,4-triazol-3(4H)-ones as newer potent antitubercular agents.

Somagond, Shilpa M; Kamble, Ravindra R; Bayannavar, Praveen K; Shaikh, Saba Kauser J; Joshi, Shrinivas D; Kumbar, Vijay M; Nesaragi, Aravind R; Kariduraganavar, Mahadevappa Y

Somagond, Shilpa M; Kamble, Ravindra R; Bayannavar, Praveen K; Shaikh, Saba Kauser J; Joshi, Shrinivas D; Kumbar, Vijay M; Nesaragi, Aravind R; Kariduraganavar, Mahadevappa Y.

Afiliação

Somagond SM; Department of Studies in Chemistry, Karnatak University Dharwad, Karnataka, India.
Kamble RR; Department of Studies in Chemistry, Karnatak University Dharwad, Karnataka, India.
Bayannavar PK; Department of Studies in Chemistry, Karnatak University Dharwad, Karnataka, India.
Shaikh SKJ; Department of Studies in Chemistry, Karnatak University Dharwad, Karnataka, India.
Joshi SD; Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry, S.E.T.'s College of Pharmacy, Dharwad, Karnataka, India.
Kumbar VM; Dr. Prabhakar Kore Basic Science Research Center, KLE University, Belagavi, Karnataka, India.
Nesaragi AR; Department of Studies in Chemistry, Karnatak University Dharwad, Karnataka, India.
Kariduraganavar MY; Department of Studies in Chemistry, Karnatak University Dharwad, Karnataka, India.

Arch Pharm (Weinheim) ; 352(10): e1900013, 2019 Oct.

Article em En | MEDLINE | ID: mdl-31397503

Assuntos

Antituberculosos/síntese química; Química Click/métodos; Cumarínicos/síntese química; Desenho de Fármacos; Mycobacterium tuberculosis/efeitos dos fármacos; Triazóis/síntese química; Antituberculosos/química; Antituberculosos/farmacologia; Cumarínicos/química; Cumarínicos/farmacologia; Testes de Sensibilidade Microbiana; Simulação de Acoplamento Molecular; Estrutura Molecular; Triazóis/química; Triazóis/farmacologia

Palavras-chave

2H-chromen-2-one; antitubercular activity; click reaction; cytotoxicity; drug likeness; molecular docking; toxicity prediction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Desenho de Fármacos / Cumarínicos / Química Click / Mycobacterium tuberculosis / Antituberculosos Tipo de estudo: Prognostic_studies Idioma: En Revista: Arch Pharm (Weinheim) Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Índia

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