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Agreement between self-reported and registry-based use of sleep medications and tranquilizers.
Evandt, Jorunn; Skurtveit, Svetlana; Oftedal, Bente; Krog, Norun Hjertager; Nafstad, Per; Skovlund, Eva; Schwarze, Per E; Aasvang, Gunn Marit.
Afiliação
  • Evandt J; Division of Infection Control and Environmental Health, Department of Air Pollution and Noise, Norwegian Institute of Public Health, Oslo, Norway.
  • Skurtveit S; Division of Mental and Physical Health, Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
  • Oftedal B; Norwegian Centre for Addiction Research (SERAF), University of Oslo, Oslo, Norway.
  • Krog NH; Division of Infection Control and Environmental Health, Department of Air Pollution and Noise, Norwegian Institute of Public Health, Oslo, Norway.
  • Nafstad P; Division of Infection Control and Environmental Health, Department of Air Pollution and Noise, Norwegian Institute of Public Health, Oslo, Norway.
  • Skovlund E; Faculty of Medicine, Department of Community Medicine and Global Health, University of Oslo, Oslo, Norway.
  • Schwarze PE; Division of Mental and Physical Health, Department of Noncommunicable Diseases, Norwegian Institute of Public Health, Oslo, Norway.
  • Aasvang GM; Division of Mental and Physical Health, Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
Pharmacoepidemiol Drug Saf ; 28(10): 1336-1343, 2019 10.
Article em En | MEDLINE | ID: mdl-31407838
ABSTRACT

PURPOSE:

The purpose of the present study was to assess the agreement between self-reported use of sleep medications and tranquilizers and dispensed hypnotics and anxiolytics.

METHODS:

Self-reported medication use was obtained from the population-based survey Health and Environment in Oslo (HELMILO) (2009-2010) (n = 13 019). Data on dispensed hypnotics and anxiolytics were obtained from the Norwegian Prescription Database (NorPD). As measures of validity, we calculated sensitivity and specificity using both self-reports and prescription records as the reference standard. Furthermore, we calculated Cohen's kappa. Current self-reported medication use was compared with prescription data in time windows of both 100 and 200 days preceding questionnaire completion.

RESULTS:

The highest sensitivity was observed for current sleep medication use in the 100-day time window (sensitivity = 0.76, 95% confidence interval [CI] 0.74, 0.79) when using prescription records as the reference standard. Sensitivity was generally lower for tranquilizers compared with sleep medications. Cohen's kappa showed the highest agreement for the 200-day time window with substantial agreement for sleep medications (kappa = 0.64; 95% CI 0.62, 0.67) and moderate agreement for tranquilizers (kappa = 0.45; 95% CI 0.41, 0.48).

CONCLUSIONS:

The present study suggests moderate to substantial agreement between self-reported use of sleep medications and tranquilizers and dispensed drugs in a general adult population. The magnitude of agreement varied according to drug category and time window. Since self-reported and registry-based use of these drug classes does not match each other accurately, limitations of each data source should be considered when such medications are applied as the exposure or outcome in epidemiologic studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tranquilizantes / Sistema de Registros / Farmacoepidemiologia / Autorrelato / Medicamentos Indutores do Sono Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Pharmacoepidemiol Drug Saf Assunto da revista: EPIDEMIOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Noruega

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tranquilizantes / Sistema de Registros / Farmacoepidemiologia / Autorrelato / Medicamentos Indutores do Sono Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Pharmacoepidemiol Drug Saf Assunto da revista: EPIDEMIOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Noruega