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Influence of Sustained Low-Efficiency Dialysis Treatment on Isavuconazole Plasma Levels in Critically Ill Patients.
Lahmer, Tobias; Batres Baires, Gonzalo; Heilmaier, Markus; Schmid, Roland M; Sörgel, Fritz; Kinzig, Martina; Huber, Wolfgang; Mayr, Ulrich; Rasch, Sebastian.
Afiliação
  • Lahmer T; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar der Technischen Universität Munich, Munich, Germany tobiaslahmer@me.com.
  • Batres Baires G; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar der Technischen Universität Munich, Munich, Germany.
  • Heilmaier M; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar der Technischen Universität Munich, Munich, Germany.
  • Schmid RM; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar der Technischen Universität Munich, Munich, Germany.
  • Sörgel F; Institute for Biomedical and Pharmaceutical Research (IBMP), Nürnberg-Heroldsberg, Germany.
  • Kinzig M; Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.
  • Huber W; Institute for Biomedical and Pharmaceutical Research (IBMP), Nürnberg-Heroldsberg, Germany.
  • Mayr U; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar der Technischen Universität Munich, Munich, Germany.
  • Rasch S; Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar der Technischen Universität Munich, Munich, Germany.
Antimicrob Agents Chemother ; 63(11)2019 11.
Article em En | MEDLINE | ID: mdl-31427296
ABSTRACT
Isavuconazole plasma concentrations were measured before and after sustained low-efficiency dialysis (SLED) treatment in 22 critically ill adult patients with probable invasive aspergillosis and underlying hematological malignancies. Isavuconazole levels were significantly lower after SLED treatment (5.73 versus 3.36 µg/ml; P < 0.001). However, even after SLED treatment, isavuconazole concentrations exceeded the in vivo MICs for several relevant Aspergillus species.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Triazóis / Estado Terminal / Antifúngicos / Nitrilas Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Triazóis / Estado Terminal / Antifúngicos / Nitrilas Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha