Sublingual nitroglycerin. II. In vitro and in vivo availability of Nitrostat and Nitrobaat tablets.
Pharm Weekbl Sci
; 10(6): 254-8, 1988 Dec 09.
Article
em En
| MEDLINE
| ID: mdl-3145488
ABSTRACT
The in vitro and in vivo availability of nitroglycerin from three compressed and one stabilized molded tablet have been studied. Compressed nitroglycerin tablets have to disintegrate before the drug is released. The disintegration and release of nitroglycerin from these tablets appeared to be strongly dependent upon conditions in the in vitro dissolution tests, such as the degree of agitation, and in vivo factors, such as tongue pressure and/or movement. The stabilized molded nitroglycerin tablet did not disintegrate but dissolved completely. Because the dissolution of the molded tablet was fast, the release rate of nitroglycerin was far less influenced by the in vitro and in vivo factors described above. The potency and in vitro and in vivo availability of fresh tablets and tablets which had been stored in tightly closed glass containers for over one year did not differ significantly. It is conjectured that the supposed potency loss of properly stored compressed nitroglycerin tablets is rather a release problem than a stability problem.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nitroglicerina
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Pharm Weekbl Sci
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Holanda