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Leveraging European infrastructures to access 1 million human genomes by 2022.
Saunders, Gary; Baudis, Michael; Becker, Regina; Beltran, Sergi; Béroud, Christophe; Birney, Ewan; Brooksbank, Cath; Brunak, Søren; Van den Bulcke, Marc; Drysdale, Rachel; Capella-Gutierrez, Salvador; Flicek, Paul; Florindi, Francesco; Goodhand, Peter; Gut, Ivo; Heringa, Jaap; Holub, Petr; Hooyberghs, Jef; Juty, Nick; Keane, Thomas M; Korbel, Jan O; Lappalainen, Ilkka; Leskosek, Brane; Matthijs, Gert; Mayrhofer, Michaela Th; Metspalu, Andres; Navarro, Arcadi; Newhouse, Steven; Nyrönen, Tommi; Page, Angela; Persson, Bengt; Palotie, Aarno; Parkinson, Helen; Rambla, Jordi; Salgado, David; Steinfelder, Erik; Swertz, Morris A; Valencia, Alfonso; Varma, Susheel; Blomberg, Niklas; Scollen, Serena.
Afiliação
  • Saunders G; ELIXIR Hub, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Baudis M; University of Zurich, Zurich, Switzerland.
  • Becker R; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg, Luxembourg.
  • Beltran S; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
  • Béroud C; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Birney E; Aix Marseille Univ, INSERM, MMG, Marseille, France.
  • Brooksbank C; Département de Génétique Médicale et de Biologie Cellulaire, APHM, Hôpital d'Enfants de la Timone, Marseille, France.
  • Brunak S; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Van den Bulcke M; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Drysdale R; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
  • Capella-Gutierrez S; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
  • Flicek P; Cancer Centre, Epidemiology and Public Health, Sciensano, Ixelles, Belgium.
  • Florindi F; ELIXIR Hub, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Goodhand P; Barcelona Supercomputing Centre (BSC), Barcelona, Spain.
  • Gut I; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Heringa J; BBMRI-ERIC, Graz, Austria.
  • Holub P; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Hooyberghs J; Global Alliance for Genomics and Health, Toronto, Ontario, Canada.
  • Juty N; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
  • Keane TM; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Korbel JO; Department of Computer Science, Vrije Universiteit, Amsterdam, Netherlands.
  • Lappalainen I; BBMRI-ERIC, Graz, Austria.
  • Leskosek B; Flemish Institute for Technological Research, VITO, Mol, Belgium.
  • Matthijs G; School of Computer Science, The University of Manchester, Manchester, UK.
  • Mayrhofer MT; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Metspalu A; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
  • Navarro A; CSC - IT Center for Science, Espoo, Finland.
  • Newhouse S; IBMI, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Nyrönen T; Katholieke Universiteit Leuven, Leuven, Belgium.
  • Page A; BBMRI-ERIC, Graz, Austria.
  • Persson B; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Palotie A; Institute of Evolutionary Biology (UPF-CSIC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
  • Parkinson H; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
  • Rambla J; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
  • Salgado D; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  • Steinfelder E; CSC - IT Center for Science, Espoo, Finland.
  • Swertz MA; Global Alliance for Genomics and Health, Toronto, Ontario, Canada.
  • Valencia A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Varma S; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala, Sweden.
  • Blomberg N; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Scollen S; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Nat Rev Genet ; 20(11): 693-701, 2019 11.
Article em En | MEDLINE | ID: mdl-31455890
ABSTRACT
Human genomics is undergoing a step change from being a predominantly research-driven activity to one driven through health care as many countries in Europe now have nascent precision medicine programmes. To maximize the value of the genomic data generated, these data will need to be shared between institutions and across countries. In recognition of this challenge, 21 European countries recently signed a declaration to transnationally share data on at least 1 million human genomes by 2022. In this Roadmap, we identify the challenges of data sharing across borders and demonstrate that European research infrastructures are well-positioned to support the rapid implementation of widespread genomic data access.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / Projeto Genoma Humano / Pesquisa Biomédica Limite: Humans País/Região como assunto: Europa Idioma: En Revista: Nat Rev Genet Assunto da revista: GENETICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / Projeto Genoma Humano / Pesquisa Biomédica Limite: Humans País/Região como assunto: Europa Idioma: En Revista: Nat Rev Genet Assunto da revista: GENETICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido