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In vivo activation of PEGylated long circulating lipid nanoparticle to achieve efficient siRNA delivery and target gene knock down in solid tumors.
Sasayama, Yumi; Hasegawa, Maki; Taguchi, Eri; Kubota, Kohei; Kuboyama, Takeshi; Naoi, Tomoyuki; Yabuuchi, Hayato; Shimai, Norie; Asano, Miyoko; Tokunaga, Akihiro; Ishii, Toshihiko; Enokizono, Junichi.
Afiliação
  • Sasayama Y; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Hasegawa M; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Taguchi E; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Kubota K; CMC R&D Center, Production Division, Kyowa Hakko Kirin Co., Ltd., 1188, Shimotogari, Nagaizumi-cho Sunto-gun, Shizuoka 194-8533, Japan.
  • Kuboyama T; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan; CMC R&D Center, Production Division, Kyowa Hakko Kirin Co., Ltd., 1188, Shimotogari, Nagaizumi-cho Sunto-gun, Shizuoka 194-8533, Japan.
  • Naoi T; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Yabuuchi H; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Shimai N; CMC R&D Center, Production Division, Kyowa Hakko Kirin Co., Ltd., 1188, Shimotogari, Nagaizumi-cho Sunto-gun, Shizuoka 194-8533, Japan.
  • Asano M; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  • Tokunaga A; Oncology Research Laboratories, Oncology R&D unit, Kyowa Hakko Kirin Co., Ltd., 1188, Shimotogari, Nagaizumi-cho Sunto-gun, Shizuoka 194-8533, Japan.
  • Ishii T; Oncology Research Laboratories, Oncology R&D unit, Kyowa Hakko Kirin Co., Ltd., 1188, Shimotogari, Nagaizumi-cho Sunto-gun, Shizuoka 194-8533, Japan.
  • Enokizono J; Research Function Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan. Electronic address: junichi.enokizono.vj@kyowakirin.com.
J Control Release ; 311-312: 245-256, 2019 10.
Article em En | MEDLINE | ID: mdl-31505222
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidiletanolaminas / Polietilenoglicóis / Proteínas Proto-Oncogênicas p21(ras) / RNA Interferente Pequeno / Nanopartículas / Neoplasias Limite: Animals / Humans / Male Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidiletanolaminas / Polietilenoglicóis / Proteínas Proto-Oncogênicas p21(ras) / RNA Interferente Pequeno / Nanopartículas / Neoplasias Limite: Animals / Humans / Male Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão