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Production of anti-Trichophyton rubrum egg yolk immunoglobulin and its therapeutic potential for treating dermatophytosis.
Xiao, Yire; Hu, Qingqing; Jiao, Luoying; Cui, Xiping; Wu, Panpan; He, Pan; Xia, Nana; Lv, Rui; Liang, Yuxin; Zhao, Suqing.
Afiliação
  • Xiao Y; Department of Pharmaceutical Engineering, Chemical Engineering and Light Industry, Guangdong University of Technology, 510006, Guangzhou, China. Electronic address: 7952315@qq.com.
  • Hu Q; Department of Pharmaceutical Engineering, Chemical Engineering and Light Industry, Guangdong University of Technology, 510006, Guangzhou, China. Electronic address: hqq2218@126.com.
  • Jiao L; Department of Pharmaceutical Engineering, Chemical Engineering and Light Industry, Guangdong University of Technology, 510006, Guangzhou, China. Electronic address: jiaoluoying@163.com.
  • Cui X; Department of Pharmaceutical Engineering, Chemical Engineering and Light Industry, Guangdong University of Technology, 510006, Guangzhou, China. Electronic address: cuixiping1989@163.com.
  • Wu P; Department of Pharmaceutical Engineering, Chemical Engineering and Light Industry, Guangdong University of Technology, 510006, Guangzhou, China. Electronic address: wyuwpp@mail2.gdut.edu.cn.
  • He P; Department of Pharmaceutical Engineering, Chemical Engineering and Light Industry, Guangdong University of Technology, 510006, Guangzhou, China. Electronic address: 1076913953@qq.com.
  • Xia N; Department of Pharmaceutical Engineering, Chemical Engineering and Light Industry, Guangdong University of Technology, 510006, Guangzhou, China. Electronic address: nanaxia6947@163.com.
  • Lv R; Department of Pharmaceutical Engineering, Chemical Engineering and Light Industry, Guangdong University of Technology, 510006, Guangzhou, China. Electronic address: m13424004193@163.com.
  • Liang Y; Department of Pharmaceutical Engineering, Chemical Engineering and Light Industry, Guangdong University of Technology, 510006, Guangzhou, China. Electronic address: lyx617022@126.com.
  • Zhao S; Department of Pharmaceutical Engineering, Chemical Engineering and Light Industry, Guangdong University of Technology, 510006, Guangzhou, China. Electronic address: sqzhao@gdut.edu.cn.
Microb Pathog ; 137: 103741, 2019 Dec.
Article em En | MEDLINE | ID: mdl-31513894
ABSTRACT
The aim of this study was to estimate the therapeutic potential of specific egg yolk immunoglobulin (IgY) on dermatophytosis caused by Trichophyton rubrum. The IgY was produced by immunizing hens with cell wall proteins of T. rubrum, extracted from eggs by PEG precipitation and then purified by ammonium sulfate precipitation. The cross-reactivity (CR) with other fungi, growth inhibition on T. rubrum in vitro and therapeutic effect on T. rubrum infection in BALB/C mice of the specific IgY were then evaluated. Anti- T. rubrum cell wall proteins IgY (anti-trCWP IgY) presented a certain degree of cross-reactivity with different fungi. In the in vitro and in vivo activity researches, Anti-trCWP IgY showed a significant dose-dependent growth inhibitory effect on T. rubrum in vitro and a significant dose-dependent therapeutic effect on T. rubrum infection in BALB/C mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tinha / Trichophyton / Imunoglobulinas / Gema de Ovo / Proteínas de Membrana / Anticorpos Antifúngicos Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Microb Pathog Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tinha / Trichophyton / Imunoglobulinas / Gema de Ovo / Proteínas de Membrana / Anticorpos Antifúngicos Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Microb Pathog Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2019 Tipo de documento: Article