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R3hdml regulates satellite cell proliferation and differentiation.
Sakamoto, Kenichi; Furuichi, Yasuro; Yamamoto, Masashi; Takahashi, Megumi; Akimoto, Yoshihiro; Ishikawa, Takahiro; Shimizu, Takahiko; Fujimoto, Masanori; Takada-Watanabe, Aki; Hayashi, Aiko; Mita, Yoshitaka; Manabe, Yasuko; Fujii, Nobuharu L; Ishibashi, Ryoichi; Maezawa, Yoshiro; Betsholtz, Christer; Yokote, Koutaro; Takemoto, Minoru.
Afiliação
  • Sakamoto K; Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Furuichi Y; Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.
  • Yamamoto M; Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Takahashi M; Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.
  • Akimoto Y; Department of Anatomy, Kyorin University School of Medicine, Tokyo, Japan.
  • Ishikawa T; Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Shimizu T; Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Chiba, Japan.
  • Fujimoto M; Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Takada-Watanabe A; Aging Stress Response Research Project Team, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
  • Hayashi A; Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Mita Y; Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Manabe Y; Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Fujii NL; Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.
  • Ishibashi R; Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.
  • Maezawa Y; Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.
  • Betsholtz C; Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Yokote K; Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Takemoto M; Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Chiba, Japan.
EMBO Rep ; 20(11): e47957, 2019 11 05.
Article em En | MEDLINE | ID: mdl-31524320
In this study, we identified a previously uncharacterized skeletal satellite cell-secreted protein, R3h domain containing-like (R3hdml). Expression of R3hdml increases during skeletal muscle development and differentiation in mice. Body weight and skeletal muscle mass of R3hdml knockout (KO) mice are lower compared to control mice. Expression levels of cell cycle-related markers, phosphorylation of Akt, and expression of insulin-like growth factor within the skeletal muscle are reduced in R3hdml KO mice compared to control mice. Expression of R3hdml increases during muscle regeneration in response to cardiotoxin (CTX)-induced muscle injury. Recovery of handgrip strength after CTX injection was significantly impaired in R3hdml KO mice, which is rescued by R3hdml. Our results indicate that R3hdml is required for skeletal muscle development, regeneration, and, in particular, satellite cell proliferation and differentiation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Células Satélites de Músculo Esquelético Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: EMBO Rep Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Células Satélites de Músculo Esquelético Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: EMBO Rep Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão