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Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells.
Pataer, Apar; Ozpolat, Bulent; Shao, RuPing; Cashman, Neil R; Plotkin, Steven S; Samuel, Charles E; Lin, Steven H; Kabil, Nashwa N; Wang, Jing; Majidi, Mourad; Fang, Bingliang; Roth, Jack A; Vaporciyan, Ara A; Wistuba, Ignacio I; Hung, Mien-Chie; Swisher, Stephen G.
Afiliação
  • Pataer A; Departments of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. apataer@mdanderson.org.
  • Ozpolat B; Departments of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Shao R; Departments of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Cashman NR; Department of Medicine (Neurology), The University of British Columbia, Vancouver, BC, Canada.
  • Plotkin SS; Vancouver Coastal Health Research Institute, Brain Research Centre, Vancouver, BC, Canada.
  • Samuel CE; Amorfix Life Sciences Ltd, Mississauga, ON, Canada.
  • Lin SH; Department of Physics & Astronomy, The University of British Columbia, Vancouver, BC, Canada.
  • Kabil NN; Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, USA.
  • Wang J; Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Majidi M; Departments of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Fang B; Departments of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Roth JA; Departments of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Vaporciyan AA; Departments of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Wistuba II; Departments of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Hung MC; Departments of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Swisher SG; Departments of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Oncogene ; 39(4): 801-813, 2020 01.
Article em En | MEDLINE | ID: mdl-31554935
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfotransferases (Aceptor do Grupo Álcool) / EIF-2 Quinase / Resposta a Proteínas não Dobradas / Proteólise / Lisossomos / Neoplasias / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfotransferases (Aceptor do Grupo Álcool) / EIF-2 Quinase / Resposta a Proteínas não Dobradas / Proteólise / Lisossomos / Neoplasias / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos