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Diagnostic and Prognostic Performance of Blood Plasma Glycan Features in the Women Epidemiology Lung Cancer (WELCA) Study.
Hu, Yueming; Ferdosi, Shadi; Kapuruge, Erandi P; Diaz de Leon, Jesús Aguilar; Stücker, Isabelle; Radoï, Loredana; Guénel, Pascal; Borges, Chad R.
Afiliação
  • Hu Y; School of Molecular Sciences and The Biodesign Institute , Arizona State University , Tempe , Arizona 85287 , United States.
  • Ferdosi S; School of Molecular Sciences and The Biodesign Institute , Arizona State University , Tempe , Arizona 85287 , United States.
  • Kapuruge EP; School of Molecular Sciences and The Biodesign Institute , Arizona State University , Tempe , Arizona 85287 , United States.
  • Diaz de Leon JA; School of Molecular Sciences and The Biodesign Institute , Arizona State University , Tempe , Arizona 85287 , United States.
  • Stücker I; CESP (Center for Research in Epidemiology and Population Health), Cancer and Environment Team, INSERM UMS1018 , University Paris-Sud, University Paris-Saclay , 94800 Villejuif, France.
  • Radoï L; CESP (Center for Research in Epidemiology and Population Health), Cancer and Environment Team, INSERM UMS1018 , University Paris-Sud, University Paris-Saclay , 94800 Villejuif, France.
  • Guénel P; Faculty of Dental Surgery , University Paris Descartes , 75006 Paris , France.
  • Borges CR; CESP (Center for Research in Epidemiology and Population Health), Cancer and Environment Team, INSERM UMS1018 , University Paris-Sud, University Paris-Saclay , 94800 Villejuif, France.
J Proteome Res ; 18(11): 3985-3998, 2019 11 01.
Article em En | MEDLINE | ID: mdl-31566983
Lung cancer is the leading cause of cancer death in women living in the United States, which accounts for approximately the same percentage of cancer deaths in women as breast, ovary, and uterine cancers combined. Targeted blood plasma glycomics represents a promising source of noninvasive diagnostic and prognostic biomarkers for lung cancer. Here, 208 samples from lung cancer patients and 207 age-matched controls enrolled in the Women Epidemiology Lung Cancer (WELCA) study were analyzed by a bottom-up glycan "node" analysis approach. Glycan features, quantified as single analytical signals, including 2-linked mannose, α2-6 sialylation, ß1-4 branching, ß1-6 branching, 4-linked GlcNAc, and antennary fucosylation, exhibited abilities to distinguish cases from controls (ROC AUCs: 0.68-0.92) and predict survival in patients (hazard ratios: 1.99-2.75) at all stages. Notable alterations of glycan features were observed in stages I-II. Diagnostic and prognostic glycan features were mostly independent of smoking status, age, gender, and histological subtypes of lung cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Biomarcadores Tumorais / Glicômica / Neoplasias Pulmonares Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Biomarcadores Tumorais / Glicômica / Neoplasias Pulmonares Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos