A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels.

Reddy, Kaalak; Jenquin, Jana R; McConnell, Ona L; Cleary, John D; Richardson, Jared I; Pinto, Belinda S; Haerle, Maja C; Delgado, Elizabeth; Planco, Lori; Nakamori, Masayuki; Wang, Eric T; Berglund, J Andrew

Reddy, Kaalak; Jenquin, Jana R; McConnell, Ona L; Cleary, John D; Richardson, Jared I; Pinto, Belinda S; Haerle, Maja C; Delgado, Elizabeth; Planco, Lori; Nakamori, Masayuki; Wang, Eric T; Berglund, J Andrew.

Afiliação

Reddy K; Center for NeuroGenetics, University of Florida College of Medicine, Gainesville, FL 32610.
Jenquin JR; The RNA Institute, University at Albany, State University of New York, Albany, NY 12222.
McConnell OL; Center for NeuroGenetics, University of Florida College of Medicine, Gainesville, FL 32610.
Cleary JD; The RNA Institute, University at Albany, State University of New York, Albany, NY 12222.
Richardson JI; Center for NeuroGenetics, University of Florida College of Medicine, Gainesville, FL 32610.
Pinto BS; Center for NeuroGenetics, University of Florida College of Medicine, Gainesville, FL 32610.
Haerle MC; The RNA Institute, University at Albany, State University of New York, Albany, NY 12222.
Delgado E; Center for NeuroGenetics, University of Florida College of Medicine, Gainesville, FL 32610.
Planco L; The RNA Institute, University at Albany, State University of New York, Albany, NY 12222.
Nakamori M; Center for NeuroGenetics, University of Florida College of Medicine, Gainesville, FL 32610.
Wang ET; Center for NeuroGenetics, University of Florida College of Medicine, Gainesville, FL 32610.
Berglund JA; Center for NeuroGenetics, University of Florida College of Medicine, Gainesville, FL 32610.

Proc Natl Acad Sci U S A ; 116(42): 20991-21000, 2019 10 15.

Article em En | MEDLINE | ID: mdl-31570586

Assuntos

Avaliação Pré-Clínica de Medicamentos/métodos; Microtúbulos/efeitos dos fármacos; Distrofia Miotônica/genética; RNA/genética; Bibliotecas de Moléculas Pequenas/farmacologia; Expansão das Repetições de Trinucleotídeos/efeitos dos fármacos; Animais; Células HeLa; Humanos; Camundongos; Camundongos Transgênicos; Microtúbulos/genética; Microtúbulos/metabolismo; Distrofia Miotônica/enzimologia; Miotonina Proteína Quinase/genética; Miotonina Proteína Quinase/metabolismo; RNA/química; RNA/metabolismo

Palavras-chave

alternative splicing; muscleblind; myotonic dystrophy; transcription

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA / Expansão das Repetições de Trinucleotídeos / Avaliação Pré-Clínica de Medicamentos / Bibliotecas de Moléculas Pequenas / Microtúbulos / Distrofia Miotônica Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article

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