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First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma.
Kim, Richard D; Sarker, Debashis; Meyer, Tim; Yau, Thomas; Macarulla, Teresa; Park, Joong-Won; Choo, Su Pin; Hollebecque, Antoine; Sung, Max W; Lim, Ho-Yeong; Mazzaferro, Vincenzo; Trojan, Joerg; Zhu, Andrew X; Yoon, Jung-Hwan; Sharma, Sunil; Lin, Zhong-Zhe; Chan, Stephen L; Faivre, Sandrine; Feun, Lynn G; Yen, Chia-Jui; Dufour, Jean-Francois; Palmer, Daniel H; Llovet, Josep M; Manoogian, Melissa; Tugnait, Meera; Stransky, Nicolas; Hagel, Margit; Kohl, Nancy E; Lengauer, Christoph; Sherwin, Cori Ann; Schmidt-Kittler, Oleg; Hoeflich, Klaus P; Shi, Hongliang; Wolf, Beni B; Kang, Yoon-Koo.
Afiliação
  • Kim RD; H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Sarker D; King's College London, London, United Kingdom.
  • Meyer T; University College London, London, United Kingdom.
  • Yau T; Queen Mary Hospital, Hong Kong, China.
  • Macarulla T; Vall d'Hebron University Hospital and Vall d'Hebrón Institute of Oncology (VHIO), Barcelona, Spain.
  • Park JW; National Cancer Center Korea, Goyang, South Korea.
  • Choo SP; National Cancer Centre Singapore, Singapore.
  • Hollebecque A; Institute Gustav Roussy, Villejuif, France.
  • Sung MW; Mount Sinai Liver Cancer Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Lim HY; Samsung Medical Center, Sungkyunkwan University, Seoul, Korea.
  • Mazzaferro V; University of Milan, Department of Oncology and Instituto Nazionale Tumori, IRCCS Foundation, Department of Surgery, HPB Surgery and Liver Transplantation, Milan, Italy.
  • Trojan J; Universitätsklinikum Frankfurt, Frankfurt, Germany.
  • Zhu AX; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Yoon JH; Seoul National University Hospital, Seoul, South Korea.
  • Sharma S; Huntsman Cancer Institute, Salt Lake City, Utah.
  • Lin ZZ; National Taiwan University Hospital, Taipei, Taiwan.
  • Chan SL; State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, China.
  • Faivre S; Hôpitaux Universitaires Paris Nord Val de Seine, Paris, France.
  • Feun LG; University of Miami, Miami, Florida.
  • Yen CJ; National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Dufour JF; University Clinic for Visceral Surgery and Medicine, Inselspital Bern, Bern, Switzerland.
  • Palmer DH; Liverpool Experimental Cancer Medicine Centre, Liverpool, United Kingdom.
  • Llovet JM; Mount Sinai Liver Cancer Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Manoogian M; Translational Research in Hepatic Oncology Group, Liver Unit, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain.
  • Tugnait M; Roche Tissue Diagnostics, Tucson, Arizona.
  • Stransky N; Blueprint Medicines Corporation, Cambridge, Massachusetts.
  • Hagel M; Blueprint Medicines Corporation, Cambridge, Massachusetts.
  • Kohl NE; Blueprint Medicines Corporation, Cambridge, Massachusetts.
  • Lengauer C; Blueprint Medicines Corporation, Cambridge, Massachusetts.
  • Sherwin CA; Blueprint Medicines Corporation, Cambridge, Massachusetts.
  • Schmidt-Kittler O; Blueprint Medicines Corporation, Cambridge, Massachusetts.
  • Hoeflich KP; Blueprint Medicines Corporation, Cambridge, Massachusetts.
  • Shi H; Blueprint Medicines Corporation, Cambridge, Massachusetts.
  • Wolf BB; Blueprint Medicines Corporation, Cambridge, Massachusetts.
  • Kang YK; Blueprint Medicines Corporation, Cambridge, Massachusetts.
Cancer Discov ; 9(12): 1696-1707, 2019 12.
Article em En | MEDLINE | ID: mdl-31575541
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piranos / Quinazolinas / Carcinoma Hepatocelular / Fatores de Crescimento de Fibroblastos / Neoplasias Hepáticas Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Discov Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piranos / Quinazolinas / Carcinoma Hepatocelular / Fatores de Crescimento de Fibroblastos / Neoplasias Hepáticas Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Discov Ano de publicação: 2019 Tipo de documento: Article