Impact of substituent effects on the design of ß-sheet mimetics and ß-double helices from (E)-vinylogous γ-amino acid oligomers.
Org Biomol Chem
; 17(41): 9226-9231, 2019 10 23.
Article
em En
| MEDLINE
| ID: mdl-31596299
ABSTRACT
Here we report the design, single crystal conformations, impact of the substituents and structural differences of two structurally important motifs, ß-sheets and ß-double helices. Though ß-sheets are common structural motifs in protein structures, ß-double helices are not common in proteins and peptides. We found that both ß-sheet mimetics and ß-double helices can be constructed from the homooligomers of α,ß-unsaturated γ-amino acids. Results suggested that introducing gem-dialkyl substitutions at the γ-carbon of the homooligomer of α,ß-unsaturated γ-amino acids resulted in the ß-double helix conformation, while the same oligomer with monosubstitution at the γ-carbon displayed a ß-sheet structure.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Índia